64801-58-7
Chemical Structure
Methotrexate-γ-aspartate
- CAS. Nr.: 64801-58-7
- Formula:C24H27N9O8
- Molecular Weight:569.53
IUPAC Name: ((S)-4-carboxy-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)butanoyl)-L-aspartic acid
InChIKey: XYYCIYYWAVAWDS-GJZGRUSLSA-N
SMILES: NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CC(O)=O)=O)=O)C)C=N2
Biological Activity: Methotrexate-γ-aspartate is a Ll210 cell dihydrofolate reductase inhibitor. Methotrexate-γ-aspartate is apparently more resistant to enzymic cleavage than is methotrexate-y-glutamate. Methotrexate-γ-aspartate can be used in antibody-targeted liposomes and is promising for research of leukemic[1].
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Methotrexate-γ-aspartate | Methotrexate-γ-aspartate is a Ll210 cell dihydrofolate reductase inhibitor. Methotrexate-γ-aspartate is apparently more resistant to enzymic cleavage than is methotrexate-y-glutamate. Methotrexate-γ-aspartate can be used in antibody-targeted liposomes and is promising for research of leukemic. | |||||||||||||||||||||
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Keywords
