Fukinolic acid
Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a receptor-operated Ca2+ channels (ROC) inhibitor, suppressing extracellular Ca2+ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca2+ channels.
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- CAS. Nr.: 50982-40-6
- Formel: C20H18O11
- Molecular Weight:434.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Fukinolic acid (300 μM; 1 h; rat aortic strips) induces relaxation of Norepinephrine-precontracted rat aortic strips with endothelium independence and suppresses Ca2+-induced contraction in Norepinephrine-preincubated rat aortic strips via extracellular Ca2+ influx inhibition[1].
Fukinolic acid (4.3 µg/mL; 4 days) reduces EV71 BrCr virus-induced cytopathic effect by 50% and causes 50% cytotoxicity at 500 µg/mL[2].
Fukinolic acid (0-230 µM; 16 h; COS-1) does not inhibit EV-A71 3C protease activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 50982-40-6
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Molecular Weight 434.35
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Formel C20H18O11
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SMILES
OC(C=C1C[C@@](C(O)=O)(O)[C@@H](C(O)=O)OC(/C=C/C2=CC(O)=C(C=C2)O)=O)=C(C=C1)O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Noguchi M, et al. Vasoactive effects of cimicifugic acids C and D, and fukinolic acid in cimicifuga rhizome. Biol Pharm Bull. 1998;21(11):1163-1168 [Content Brief]
[2]. Ma Y, et al. Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection. Int J Antimicrob Agents. 2019;53(2):128-136. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Fukinolic acid Related Classifications
HY-N15737 Related Classifications
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