Xpo1 - exportin 1 Gene

Also Known as Crm1; Exp1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 103573

Summary

Enables nuclear export signal receptor activity. Acts upstream of or within several processes, including protein export from nucleus; regulation of centrosome duplication; and regulation of protein export from nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; early embryo; nervous system; respiratory system; and sensory organ. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Apr 2022]

Xpo1 Products (5)

mRNA	Protein	Name
NM_001035226.1	NP_001030303.1	exportin-1
NM_001412406.1	NP_001399335.1	exportin-1
NM_001412407.1	NP_001399336.1	exportin-1
NM_001412408.1	NP_001399337.1	exportin-1
NM_134014.3	NP_598775.2	exportin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables nuclear export signal receptor activity	IDA IDA: Inferred from direct assay	12446771	MGI
enables nuclear export signal receptor activity	IMP IMP: Inferred from mutant phenotype	12446771	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10438867	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
involved in mRNA export from nucleus	IDA IDA: Inferred from direct assay	31340148	MGI
involved in mRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	31340148	MGI
acts upstream of or within protein export from nucleus	IDA IDA: Inferred from direct assay	11796723	MGI
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	18606808	MGI
acts upstream of or within protein export from nucleus	IMP IMP: Inferred from mutant phenotype	11092755	MGI
acts upstream of or within protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	16297385	MGI
acts upstream of or within regulation of centrosome duplication	IMP IMP: Inferred from mutant phenotype	16297385	MGI
acts upstream of or within regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	15767664	MGI
acts upstream of or within regulation of protein export from nucleus	IMP IMP: Inferred from mutant phenotype	14981260	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nucleus	IDA IDA: Inferred from direct assay	16297385	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
exportin-1	chromosome region maintenance 1 protein homolog exportin 1, CRM1 homolog

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-100423	Eltanexor	Inhibitor	99.84%	Phase 2
HY-15970	Verdinexor		99.94%	Phase 1

Pre-clinical Phase

Bioactive Molecules (15)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-170669	PROTAC XPO1 degrader-1		99.77%	Unkown
HY-164710	Biotinylated leptomycin B		99.32%	Unkown
HY-144763	XPO1-IN-1	Inducer	98.08%	Unkown
HY-W010525	Piperidin-4-ylmethanamine		99.94%	Unkown
HY-RS15889	XPO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-113902	(2-(β-Piperidinoethyl)-9-hydroxyellipticinium chloride	Inhibitor	/	Unkown
HY-161391	CW0134	Modulator	/	Unkown
HY-161392	CW2158	Modulator	/	Unkown
HY-170671	E3 ligase Ligand 49		/	Unkown
HY-170672	XPO1-ligand-1	Ligand	/	Unkown
HY-170673	E3 Ligase Ligand-linker Conjugate 156		/	Unkown
HY-174132	CW8001	Inhibitor	/	Unkown
HY-163902	SP100030 analogue 1	Inhibitor	/	Unkown
HY-RS16700	Xpo1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23134	Xpo1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xpo1	NCBI	NCBI:7514