SP100030 analogue 1
SP100030 analogue 1 (compound 11), a SP100030 (HY-110177) analogue, is a selective inhibitor of transcriptional activation (SITA) with an EC50 of 137 nM for suppressing the XPO1-dependent upregulation of IL2 by Jurkat-based IL2-Luc reporter assay.
For research use only. We do not sell to patients.
- CAS No.: 154934-68-6
- Formula: C13H5ClF7N3O
- Molecular Weight:387.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | EC50 |
1610 nM
Compound: 11
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Cytotoxicity against human Jurkat cells incubated for 24 hrs by celltiter glo assay
Cytotoxicity against human Jurkat cells incubated for 24 hrs by celltiter glo assay
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[PMID: 39005064] |
Chemical Information
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CAS No. 154934-68-6
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Molecular Weight 387.64
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Formula C13H5ClF7N3O
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SMILES
O=C(C1=CN=C(N=C1C(F)(F)F)Cl)NC2=CC(F)=CC(C(F)(F)F)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SP100030 analogue 1 Related Classifications
HY-163902 Related Classifications
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