Scrib - scribbled planar cell polarity Gene

Also Known as Crc; CRIB; Scrb1; SCRIB1; vartul; mKIAA0147

Species: Mus musculus

Gene Type: protein coding
Gene ID: 105782

Summary

Involved in several processes, including establishment of T cell polarity; negative regulation of activated T cell proliferation; and synaptic vesicle cycle. Acts upstream of or within several processes, including nervous system development; post-anal tail morphogenesis; and wound healing. Located in several cellular components, including basolateral plasma membrane; immunological synapse; and myelin sheath abaxonal region. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; hair follicle; and nervous system. Orthologous to human SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Apr 2022]

Scrib Products (3)

mRNA Protein Name
NM_001310542.1 NP_001297471.1 protein scribble homolog isoform 2
NM_001310543.1 NP_001297472.1 protein scribble homolog isoform 3
NM_134089.2 NP_598850.1 protein scribble homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16611247 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within auditory receptor cell morphogenesis IGI
IGI: Inferred from genetic interaction
20215345 MGI
acts upstream of or within auditory receptor cell stereocilium organization IGI
IGI: Inferred from genetic interaction
20215345 MGI
involved in cell migration IMP
IMP: Inferred from mutant phenotype
18716323 MGI
acts upstream of or within cochlear nucleus development IGI
IGI: Inferred from genetic interaction
20215345 MGI
involved in establishment of T cell polarity IDA
IDA: Inferred from direct assay
18329370 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
21515572 MGI
involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
19041750 MGI
acts upstream of or within morphogenesis of embryonic epithelium IMP
IMP: Inferred from mutant phenotype
12499390 MGI
involved in negative regulation of activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
18329370 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
21515572 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
20643356 MGI
involved in positive chemotaxis IMP
IMP: Inferred from mutant phenotype
18716323 MGI
involved in positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
18329370 MGI
acts upstream of or within post-anal tail morphogenesis IGI
IGI: Inferred from genetic interaction
21515572 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
21515572 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
16687519 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
19458197 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
19458197 MGI
involved in synaptic vesicle targeting IMP
IMP: Inferred from mutant phenotype
19458197 MGI
acts upstream of or within wound healing IGI
IGI: Inferred from genetic interaction
20643356 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16687519 MGI
located in cell-cell contact zone IDA
IDA: Inferred from direct assay
22333836 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
18329370 MGI
located in myelin sheath abaxonal region IDA
IDA: Inferred from direct assay
20237282 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein scribble homolog

  • PDZ-domain protein scribble

  • circletail

  • scribble homolog 1

  • scribbled homolog

Scrib Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Scrib Q80U72 Crtam Mus musculus Q149L7
Confocal
18329370
Cross
Scrib Q80U72 PHLPP1 Homo sapiens O60346
Anti Tag CoIP
21701506
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-175276 JNK-IN-24 Inhibitor / Unkown
HY-RS12562 SCRIB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scrib NCBI NCBI:23513