POLR3G - RNA polymerase III subunit G Gene

Also Known as C31; RPC7; RPC32

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10622

About POLR3G

Cytogenetic location: 5q14.3 Genomic coordinates (GRCh38): 5:90,473,929-90,514,557 (from NCBI)

This gene has 7 transcripts (splice variants) and 19 orthologues. Broad expression in testis (RPKM 1.8), esophagus (RPKM 1.0) and 24 other tissues.

Summary

Enables chromatin binding activity. Involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and transcription by RNA polymerase III. Acts upstream of or within cell population proliferation. Located in cytosol and nuclear body. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]

POLR3G Products (5)

mRNA Protein Name
NM_001370351.1 NP_001357280.1 DNA-directed RNA polymerase III subunit RPC7 isoform 1
NM_001370352.1 NP_001357281.1 DNA-directed RNA polymerase III subunit RPC7 isoform 2
NM_001370353.1 NP_001357282.1 DNA-directed RNA polymerase III subunit RPC7 isoform 2
NM_001370354.1 NP_001357283.1 DNA-directed RNA polymerase III subunit RPC7 isoform 1
NM_006467.3 NP_006458.2 DNA-directed RNA polymerase III subunit RPC7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables chromatin binding IDA
IDA: Inferred from direct assay
24107381 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20154270 GOA
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within cell population proliferation IEP
IEP: Inferred from expression pattern
24107381 GOA
involved in positive regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
19609254 GOA
involved in positive regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
19609254 GOA
involved in transcription by RNA polymerase III IDA
IDA: Inferred from direct assay
20154270 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of RNA polymerase III complex IDA
IDA: Inferred from direct assay
24107381 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20154270 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR3G Protein Structure

RNA_pol_3_Rpc31

RNA_pol_3_Rpc31: DNA-directed RNA polymerase III subunit Rpc31 (1 - 223)

  • 0
  • 100
  • 200
  • 223 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase III subunit RPC7

  • DNA-directed RNA polymerase III 32 kDa polypeptide

POLR3G Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
POLR3G O15318 POLR3C Homo sapiens Q9BUI4
Anti Tag CoIP
35271311
Intra
POLR3G O15318 POLR3C Homo sapiens Q9BUI4
Anti Tag CoIP
20154270
Intra
POLR3G O15318 POLR3C Homo sapiens Q9BUI4
Validated Y2H
32296183
Intra
POLR3G O15318 POLR3F Homo sapiens Q9H1D9
Anti Tag CoIP
35271311
Intra
POLR3G O15318 POLR3F Homo sapiens Q9H1D9
Anti Tag CoIP
20154270
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cerebellofaciodental Syndrome

  • Cerebellar-Facial-Dental Syndrome

  • CFDS
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10860 POLR3G Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus POLR3G RGD RGD:1593792
Canis familiaris POLR3G VGNC VGNC:44805
Bos taurus POLR3G VGNC VGNC:33151
Macaca mulatta POLR3G VGNC VGNC:84480
Mus musculus POLR3G MGD MGI:1914736
Others POLR3G NCBI