GPC4 - glypican 4 Gene

Also Known as KPTS; K-glypican

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2239

About GPC4

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:133,300,103-133,415,489 (from NCBI)

This gene has 1 transcript (splice variant), 203 orthologues, 5 paralogues and is associated with 6 phenotypes. Broad expression in placenta (RPKM 22.5), kidney (RPKM 16.2) and 22 other tissues.

Summary

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]

GPC4 Products (1)

mRNA Protein Name
NM_001448.3 NP_001439.2 glypican-4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
29276006 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
10585884 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPC4 Protein Structure

Glypican

Glypican: Glypican (10 - 555)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 556 a.a.
Protein Preferred Names Protein Names

glypican-4

  • dJ900E8.1 (glypican 4)

GPC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
GPC4 O75487 GPC6 Homo sapiens Q9Y625
Anti Tag CoIP
33961781
Intra
GPC4 O75487 GPC6 Homo sapiens Q9Y625
Anti Tag CoIP
28514442
Intra
GPC4 O75487 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
GPC4 O75487 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
GPC4 O75487 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Keipert Syndrome

  • Nasodigitoacoustic Syndrome

  • KPTS

  • Nasodigitoacoustic Syndrome, Formerly
Simpson-Golabi-Behmel Syndrome, Type 1

  • Simpson-Golabi-Behmel Syndrome Type 1

  • Simpson-Golabi-Behmel Syndrome

  • SGBS1

  • Golabi-Rosen Syndrome

  • Simpson Dysmorphia Syndrome

  • Sgbs

  • Bulldog Syndrome

  • Dgsx

  • Sdys

  • Dysplasia Gigantism Syndrome, X-Linked

  • X-Linked Dysplasia Gigantism Syndrome

  • Dgsx Golabi-Rosen Syndrome

  • Sara Angers Syndrome

  • Sgb Syndrome

  • Mental Retardation-Overgrowth Syndrome

  • Simpson Dysplasia Syndrome

  • Simpson Syndrome

  • Simpson-Golabi-Behmel Syndrome 1

  • Dysplasia Gigantism Syndrome X-Linked
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Craniosynostosis

  • Premature Closure Of Cranial Sutures

  • Craniostenosis

  • Craniosynostosis Syndrome

  • Cso

  • Craniosynostoses

  • Congenital Ossification Of Cranial Sutures

  • Congenital Ossification Of Sutures Of Skull

  • Craniostosis

  • Imperfect Fusion Of Skull

  • Congenital Imperfect Closure Skull

  • Imperfect Closure Skull

  • Premature Closure Cranium Sutures

  • Deficiency Of Craniofacial Axis
Omodysplasia

  • Omodysplasia Type 1

  • Omodysplasia 2
Hereditary Multiple Exostoses

  • Multiple Congenital Exostosis

  • Hereditary Multiple Exostoses 1

  • Hereditary Multiple Exostoses 2

  • Hereditary Multiple Exostoses 3

  • Multiple Exostosis Syndromes

  • Multiple Ostechondromas

  • Osteochondromatosis Syndrome

  • Exostoses Multiple Hereditary

  • Exostoses, Multiple Hereditary
Exostosis

  • Osteophyte

  • Exostoses

  • Orbital Exostosis

  • Exostosis Of Orbit

  • Bone Spur

  • Bony Outgrowth

  • Swimmer'S Exostosis

  • Osteophytes

  • External Exotoses

  • Cartilaginous Exostosis
Robinow Syndrome

  • Acral Dysostosis With Facial And Genital Abnormalities

  • Fetal Face Syndrome

  • Robinow Dwarfism

  • Mesomelic Dwarfism-Small Genitalia Syndrome

  • Robinow-Silverman-Smith Syndrome

  • Costovertebral Segmentation Defect With Mesomelia

  • Covesdem Syndrome

  • Robinow'S Syndrome

  • Robinow-Silverman Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS05629 GPC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GPC4 RGD RGD:1359399
Bos taurus GPC4 VGNC VGNC:29526
Canis familiaris GPC4 VGNC VGNC:41374
Felis catus GPC4 VGNC VGNC:67406
Mus musculus GPC4 MGD MGI:104902
Macaca mulatta GPC4 VGNC VGNC:73118
Others GPC4 NCBI