GPC6 - glypican 6 Gene
Also Known as OMIMD1
Species: Homo sapiens
About GPC6
This gene has 2 transcripts (splice variants), 282 orthologues, 5 paralogues and is associated with 3 phenotypes. Broad expression in gall bladder (RPKM 6.5), urinary bladder (RPKM 3.9) and 21 other tissues.
Summary
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]
GPC6 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_005708.5 | NP_005699.1 | glypican-6 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
28514442 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in cell migration |
IDA
IDA: Inferred from direct assay
|
21871017 | GOA |
GPC6 Protein Structure
Glypican: Glypican (15 - 553)
- 0
- 100
- 200
- 300
- 400
- 500
- 555 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
glypican-6 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Omodysplasia 1 |
|
|
| Omodysplasia |
|
|
| Keipert Syndrome |
|
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| Simpson-Golabi-Behmel Syndrome, Type 1 |
|
|
| Hereditary Multiple Exostoses |
|
|
| Breast Cancer |
|
|
| Body Dysmorphic Disorder |
|
|
| Osteochondrodysplasia |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | GPC6 | VGNC | VGNC:106263 |
| Rattus norvegicus | GPC6 | RGD | RGD:1593308 |
| Mus musculus | GPC6 | MGD | MGI:1346322 |
| Felis catus | GPC6 | VGNC | VGNC:102215 |
| Others | GPC6 | NCBI |