WDTC1 - WD and tetratricopeptide repeats 1 Gene

Also Known as ADP; DCAF9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23038

About WDTC1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,234,441-27,308,636 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 28.2), heart (RPKM 14.1) and 25 other tissues.

Summary

Predicted to enable enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to act upstream of or within several processes, including cellular response to Insulin stimulus; glucose metabolic process; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin Ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

WDTC1 Products (3)

mRNA Protein Name
NM_001276252.2 NP_001263181.1 WD and tetratricopeptide repeats protein 1 isoform a
NM_001410767.1 NP_001397696.1 WD and tetratricopeptide repeats protein 1 isoform c
NM_015023.5 NP_055838.2 WD and tetratricopeptide repeats protein 1 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16964240 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDTC1 Protein Structure

WD40

WD40: WD domain, G-beta repeat (41 - 75)

WD40

WD40: WD domain, G-beta repeat (81 - 120)

WD40

WD40: WD domain, G-beta repeat (126 - 163)

TPR_11

TPR_11: TPR repeat (366 - 430)

TPR_2

TPR_2: Tetratricopeptide repeat (434 - 457)

WD40

WD40: WD domain, G-beta repeat (531 - 566)

WD40

WD40: WD domain, G-beta repeat (572 - 608)

  • 0
  • 200
  • 400
  • 600
  • 677 a.a.
Protein Preferred Names Protein Names

WD and tetratricopeptide repeats protein 1

  • DDB1 and CUL4 associated factor 9

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS15804 WDTC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus WDTC1 RGD RGD:1310362
Felis catus WDTC1 VGNC VGNC:67067
Mus musculus WDTC1 MGD MGI:2685541
Canis familiaris WDTC1 VGNC VGNC:48400
Macaca mulatta WDTC1 VGNC VGNC:79784
Bos taurus WDTC1 VGNC VGNC:107027
Others WDTC1 NCBI