Cacna1c - calcium voltage-gated channel subunit alpha1 C Gene

Also Known as RATIVS302

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24239

Summary

Enables several functions, including high voltage-gated Calcium Channel activity; protein Phosphatase 2A binding activity; and transmembrane transporter binding activity. Involved in calcium ion transport; cellular response to amyloid-beta; and positive regulation of calcium ion transmembrane transport via high voltage-gated Calcium Channel. Located in several cellular components, including T-tubule; postsynaptic density; and synaptic membrane. Part of L-type voltage-gated Calcium Channel complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with Z disc. Human ortholog(s) of this gene implicated in Brugada syndrome 3 and Timothy syndrome. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1c Products (1)

mRNA Protein Name
NM_012517.2 NP_036649.2 voltage-dependent L-type calcium channel subunit alpha-1C

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables high voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
17068255 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15140941 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
14569017 RGD
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
16519540 RGD
enables translation initiation factor binding IPI
IPI: Inferred from physical interaction
23737983 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
11576544 RGD
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
15140941 RGD
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
16483597 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in axon development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in calcium ion import IMP
IMP: Inferred from mutant phenotype
19422800 RGD
involved in calcium ion transmembrane transport via high voltage-gated calcium channel IDA
IDA: Inferred from direct assay
15170217 RGD
involved in calcium ion transmembrane transport via high voltage-gated calcium channel IMP
IMP: Inferred from mutant phenotype
18562674 RGD
involved in calcium ion transport IMP
IMP: Inferred from mutant phenotype
16483597 RGD
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
21822937 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in corpus callosum development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in exocytosis IMP
IMP: Inferred from mutant phenotype
18562674 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
IMP: Inferred from mutant phenotype
25675390 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
18562674 RGD
involved in positive regulation of membrane depolarization IMP
IMP: Inferred from mutant phenotype
18562674 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
27905406 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
20873977 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
27905406 RGD
Cellular Component GO Annotation Evidence Verweise Source
part of L-type voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
15170217 RGD
located in T-tubule IDA
IDA: Inferred from direct assay
14569017 RGD
located in Z disc IDA
IDA: Inferred from direct assay
11053140 RGD
located in axon IDA
IDA: Inferred from direct assay
22473424 RGD
located in cell surface IDA
IDA: Inferred from direct assay
21822937 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15140941 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18067152 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15140941 RGD
NOT located in nucleus IDA
IDA: Inferred from direct assay
15140941 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
15140941 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
18067152 RGD
NOT located in presynaptic membrane IDA
IDA: Inferred from direct assay
15140941 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
18067152 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17068255 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
16483597 RGD
part of voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
16554304 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent L-type calcium channel subunit alpha-1C

  • L-type calcium channel alpha-1 subunit

  • RBC

  • brain class C

  • calcium channel, voltage-dependent, L type, alpha 1C subunit

  • calcium channel, voltage-dependent, alpha 1C subunit

  • voltage-gated calcium channel subunit alpha Cav1.2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS01793 CACNA1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21233 Cacna1c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27750 Cacna1c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacna1c NCBI NCBI:775
Susscrofa domestica Cacna1c NCBI