TNFRSF19 - TNF receptor superfamily member 19 Gene

Also Known as TAJ; TROY; TRADE; TAJ-alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55504

About TNFRSF19

Cytogenetic location: 13q12.12 Genomic coordinates (GRCh38): 13:23,570,412-23,676,093 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 2 paralogues. Biased expression in skin (RPKM 37.6), prostate (RPKM 12.9) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing Apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

TNFRSF19 Products (5)

mRNA Protein Name
NM_001204458.3 NP_001191387.1 tumor necrosis factor receptor superfamily member 19 isoform 2 precursor
NM_001204459.2 NP_001191388.1 tumor necrosis factor receptor superfamily member 19 isoform 3
NM_001354985.2 NP_001341914.1 tumor necrosis factor receptor superfamily member 19 isoform 4 precursor
NM_018647.5 NP_061117.2 tumor necrosis factor receptor superfamily member 19 isoform 1 precursor
NM_148957.4 NP_683760.1 tumor necrosis factor receptor superfamily member 19 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
30337686 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 19

  • toxicity and JNK inducer

TNFRSF19 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TNFRSF19 Q9NS68 PHB1 Homo sapiens P35232
Anti Bait CoIP
30337686
Intra
TNFRSF19 Q9NS68 PHB1 Homo sapiens P35232
IF
30337686
Intra
TNFRSF19 Q9NS68 ARHGDIA Homo sapiens P52565
IF
30337686
Intra
TNFRSF19 Q9NS68 ARHGDIA Homo sapiens P52565
Anti Bait CoIP
30337686
Intra
TNFRSF19 Q9NS68 PEBP1 Homo sapiens P30086
IF
30337686
Intra
TNFRSF19 Q9NS68 PEBP1 Homo sapiens P30086
Anti Bait CoIP
30337686
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF19 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P73572 TROY/TNFRSF19 Protein, Human (HEK293, His) Q9NS68-2 (E30-L170) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73573 TROY/TNFRSF19 Protein, Human (HEK293, Fc) Q9NS68-2 (M1-L170) ≥ 85%, as determined by reducing SDS-PAGE.

TNFRSF19 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P83120 TNFRSF19 Antibody (YA2865) WB, IHC-P, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Ectodermal Dysplasia

  • Congenital Ectodermal Defect

  • Congenital Ectodermal Dysplasia

  • Ectodermal Dysplasia Syndrome

  • Dysplasia, Ectodermal
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

  • Hypohidrotic Ectodermal Dysplasia

  • Hed

  • Anhidrotic Ectodermal Dysplasia

  • Ectodermal Dysplasia, Hypohidrotic

  • Eda

  • Christ-Siemens-Touraine Syndrome

  • ECTD10B

  • Ectodermal Dysplasia Anhidrotic

  • Ectodermal Dysplasia, Anhidrotic

  • Cst Syndrome

  • Ectodermal Dysplasia Hypohidrotic Autosomal Recessive

  • Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive

  • Dysplasia, Ectodermal, Hypohidrotic

  • Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

  • Ectodermal Dysplasia 3, Anhidrotic

  • Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14809 TNFRSF19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19852 Tnfrsf19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26352 Tnfrsf19 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TNFRSF19 MGD MGI:1352474
Bos taurus TNFRSF19 VGNC VGNC:53840
Canis familiaris TNFRSF19 VGNC VGNC:47661
Felis catus TNFRSF19 VGNC VGNC:66407
Rattus norvegicus TNFRSF19 RGD RGD:1564996
Macaca mulatta TNFRSF19 VGNC VGNC:78588
Others TNFRSF19 NCBI