PHB1 - prohibitin 1 Gene

Also Known as PHB; HEL-215; HEL-S-54e

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5245

About PHB1

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,404,052-49,414,882 (from NCBI)

This gene has 16 transcripts (splice variants), 245 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 68.3), colon (RPKM 44.2) and 25 other tissues.

Summary

This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PHB1 Products (4)

mRNA	Protein	Name
NM_001281496.2	NP_001268425.1	prohibitin 1 isoform 1
NM_001281497.2	NP_001268426.1	prohibitin 1 isoform 2
NM_001281715.2	NP_001268644.1	prohibitin 1 isoform 1
NM_002634.4	NP_002625.1	prohibitin 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables complement component C3a binding	IDA IDA: Inferred from direct assay	17070910	GOA
enables complement component C3b binding	IDA IDA: Inferred from direct assay	17070910	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16964284	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11302691	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	28017329	GOA
enables proteinase activated receptor binding	IPI IPI: Inferred from physical interaction	24732013	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	18487222	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RIG-I signaling pathway	IDA IDA: Inferred from direct assay	31522117	GOA
involved in T-helper 17 type immune response	IDA IDA: Inferred from direct assay	31899195	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	31522117	GOA
involved in cellular response to interleukin-6	IDA IDA: Inferred from direct assay	17324931	GOA
involved in epigenetic regulation of gene expression	IDA IDA: Inferred from direct assay	12466959	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	17008324	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12065415	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18487222	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	24732013	GOA
involved in negative regulation of androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	16964284	GOA
involved in negative regulation of androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18487222	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	12065415	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18487222	GOA
involved in negative regulation of glucocorticoid receptor signaling pathway	IDA IDA: Inferred from direct assay	16964284	GOA
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	24732013	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16964284	GOA
involved in negative regulation of transcription by competitive promoter binding	IDA IDA: Inferred from direct assay	18487222	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14500729	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22417827	GOA
involved in positive regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24732013	GOA
involved in positive regulation of complement activation	IDA IDA: Inferred from direct assay	17070910	GOA
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	26310625	GOA
involved in positive regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	31899195	GOA
acts upstream of positive regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	26310625	GOA
involved in progesterone receptor signaling pathway	IDA IDA: Inferred from direct assay	16964284	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	18339324	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	17008324	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14500729	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	22417827	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16964284	GOA
located in early endosome	IDA IDA: Inferred from direct assay	24732013	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	17008324	GOA
part of mitochondrial prohibitin complex	IDA IDA: Inferred from direct assay	31522117	GOA
part of mitochondrial prohibitin complex	IPI IPI: Inferred from physical interaction	20959514	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	24732013	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	12466959	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16964284	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15274632	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHB1 Protein Structure

Band_7

0
100
200
272 a.a.

Protein Preferred Names	Protein Names
prohibitin 1	epididymis luminal protein 215

PHB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PHB1	P35232	LONRF3	Homo sapiens	Q496Y0	Display Tech	20195357
Intra	PHB1	P35232	PHB2	Homo sapiens	Q99623	Anti Bait CoIP	20959514
Intra	PHB1	P35232	PHB2	Homo sapiens	Q99623	Crosslink	30021884
Intra	PHB1	P35232	TP53	Homo sapiens	P04637	Anti Bait CoIP	20134482
Intra	PHB1	P35232	TP53	Homo sapiens	P04637	Confocal	16319068
Intra	PHB1	P35232	TP53	Homo sapiens	P04637	IF	24380853
Intra	PHB1	P35232	SKP2	Homo sapiens	Q13309-2	Anti Bait CoIP	20134482
Intra	PHB1	P35232	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

PHB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83438	Prohibitin Antibody (YA3183)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
HY-P83438A	Prohibitin Antibody (YA3183)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
HY-P84273	Prohibitin Antibody (YA3970)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P84273A	Prohibitin Antibody (YA3970)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P85336	Prohibitin Antibody (YA5028)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue; IP; FC	Human, Mouse, Rat
HY-P86584	Prohibitin Antibody (YA6276)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
3-Methylglutaconic Aciduria, Type V	3-Methylglutaconic Aciduria Type 5 Mga5 MGCA5 Dcma Dcma Syndrome Dilated Cardiomyopathy With Ataxia 3-Methylglutaconic Aciduria Type V Mga Type V Cardiomyopathy, Dilated, With Ataxia Mga, Type V Dilated Cardiomyopathy With Ataxia Syndrome Dnajc19 Defect 3-Methylglutaconic Aciduria 5 3-Alpha-Methylglutaconic Aciduria Type 5 3-@Methylglutaconic Aciduria, Type V
Parkinson Disease 4, Autosomal Dominant	Autosomal Dominant Parkinson Disease 4 PARK4 Parkinson Disease 4, Autosomal Dominant Lewy Body Parkinson Disease 4 Parkinson'S Disease 4 Autosomal Dominant Lewy Body Parkinson Disease 4 Autosomal Dominant Parkinson'S Disease 4 Parkinson Disease 4 Autosomal Dominant Lewy Body Parkinson Disease Autosomal Dominant 4 Parkinson Disease Familial Type 4 Parkinson Disease, Type 4
3-Methylglutaconic Aciduria, Type Iii	Optic Atrophy 3-Methylglutaconic Aciduria Type 3 Costeff Syndrome Mga3 Costeff Optic Atrophy Syndrome Optic Atrophy Plus Syndrome Infantile Optic Atrophy With Chorea And Spastic Paraplegia 3-Methylglutaconic Aciduria Type Iii Autosomal Recessive Optic Atrophy Plus Syndrome Autosomal Recessive Optic Atrophy Type 3 Opa3 Defect MGCA3 Mga, Type Iii Iraqi Jewish Optic Atrophy Plus Mga Type Iii Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia Iraqi-Jewish 'Optic Atrophy Plus' Optic Atrophy 3, Autosomal Recessive Opa3, Autosomal Recessive Opa3-Related 3-Methylglutaconic Aciduria Iraqi-Jewish Optic Atrophy Plus Atrophy Of Optic Disc 3-Alpha Methylglutaconic Aciduria Type Iii Optic Atrophy 3 Optic Atrophy Infantile With Chorea And Spastic Paraplegia Autosomal Recessive Opa3 Autosomal Recessive Optic Atrophy 3 3-Methylglutaconic Aciduria 3 3-Alpha-Methylglutaconic Aciduria Type 3 Optic Atrophy 3 Autosomal Recessive Atrophy, Optic Atrophy, Optic, Plus Syndrome Optic Nerve Atrophy Primary Optic Atrophy Oa - [Optic Atrophy] Second Cranial Nerve Atrophy Second Cranium Nerve Atrophy
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114989	Fluorizoline	Inducer	99.77%	Unkown
HY-162904	BPU17		98.16%	Unkown
HY-141475	Acetoacetyl coenzyme A sodium		/	Unkown
HY-RS10407	PHB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17295	Phb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23750	Phb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PHB1	VGNC	VGNC:55714
Mus musculus	PHB1	MGD	MGI:97572
Macaca mulatta	PHB1	VGNC	VGNC:99194
Rattus norvegicus	PHB1	RGD	RGD:3322
Bos taurus	PHB1	VGNC	VGNC:32808
Others	PHB1	NCBI