PHB2 - prohibitin 2 Gene

Homo sapiens

Also known as BAP; REA; p22; hBAP; Bap37; BCAP37; PNAS-141

Gene ID: 11331 | Gene type: protein coding

About PHB2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,965,327-6,970,753 (from NCBI)

This gene has 20 transcripts (splice variants), 251 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 111.2), duodenum (RPKM 62.9) and 25 other tissues.

Summary

Enables several functions, including protein C-terminus binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in several processes, including defense response to virus; positive regulation of cell cycle phase transition; and regulation of transcription, DNA-templated. Located in several cellular components, including cell surface; mitochondrial membrane; and nuclear matrix. Part of mitochondrial prohibitin complex. [provided by Alliance of Genome Resources, Apr 2022]

PHB2 Products(2)

mRNA	Protein	Name
NM_001144831.2	NP_001138303.1	prohibitin-2 isoform 1
NM_001267700.1	NP_001254629.1	prohibitin-2 isoform 3

PHB2 Protein Structure

Band_7

0
100
200
299 a.a.

Protein Preferred Names

Protein Names

prohibitin-2

B cell receptor associated protein 37

Related Diseases

Diseases

Alias

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Breast Medullary Carcinoma

Medullary Breast Carcinoma	Medullary Breast Carcinoma With Lymphoid Stroma
Medullary Carcinoma Of Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114989	Fluorizoline	Inducer	99.77%	Unkown
HY-152093	YL-939	Inhibitor	98.97%	Unkown
HY-117113	JI051	Inhibitor	≥98.0%	Unkown
HY-124484	JI130	Inhibitor	99.01%	Unkown
HY-RS10408	PHB2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PHB2	VGNC	VGNC:44476
Macaca mulatta	PHB2	VGNC	VGNC:100088
Bos taurus	PHB2	VGNC	VGNC:32809
Felis catus	PHB2	VGNC	VGNC:64132
Rattus norvegicus	PHB2	RGD	RGD:620203
Mus musculus	PHB2	MGD	MGI:102520
Macaca fascicularis	PHB2	NCBI
Others	PHB2	NCBI

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