YL-939 

YL-939 is a potent ferroptosis inhibitor. YL-939 inhibits ferroptosis by targeting the PHB2/ferritin/iron axis^[1].

YL-939 (0.01-10 μM) efficiently protects cells from ferroptosis with IC₅₀ values of 0.14 μM, 0.25 μM, 0.16 μM, 0.16 μM and 0.24 μM for HT-1080, Miapaca-2, Calu-1, HCT116 and SHSY5Y cells, respectively^[1].
YL-939 (5 μM; 10 h; ES-2 cells) reduces the level of ROS in cytosolic, membrane lipids^[1].
YL-939 (5 μM; 1-10 h; ES-2 cells) has a biological target of PHB2^[1].
YL-939 (3 μM; 10 h; ES-2 cells) improves ferritin protein expression in a concentration-dependent manner and blocks autophagosomes/lysosomes, and hence inhibited ferritinophagy^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YL-939 (3 mg/kg; i.p.; single injection) ameliorates liver damage in an Acetaminophen (APAP)-induced acute liver injury mode^[1]l.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

426.51

C₂₅H₂₆N₆O

C1(C2=CN3C=C(N=C(C3=N2)C4=CCOCC4)C5=CN(N=C5)C6CCNCC6)=CC=CC=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yang W, et, al. Non-classical ferroptosis inhibition by a small molecule targeting PHB2. Nat Commun. 2022 Dec 3;13(1):7473.  [Content Brief]