RALGAPB - Ral GTPase activating protein non-catalytic subunit beta Gene

Also Known as KIAA1219; RalGAPbeta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57148

About RALGAPB

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,472,843-38,578,858 (from NCBI)

This gene has 9 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in thyroid (RPKM 11.6), testis (RPKM 11.5) and 25 other tissues.

Summary

Enables protein heterodimerization activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within Ral protein signal transduction; regulation of exocyst localization; and regulation of protein localization. [provided by Alliance of Genome Resources, Apr 2022]

RALGAPB Products (3)

mRNA Protein Name
NM_001282917.2 NP_001269846.1 ral GTPase-activating protein subunit beta isoform 1
NM_001282918.2 NP_001269847.1 ral GTPase-activating protein subunit beta isoform 2
NM_020336.4 NP_065069.1 ral GTPase-activating protein subunit beta isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
19520869 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ral GTPase-activating protein subunit beta

  • Ral GTPase activating protein non-catalytic beta subunit

RALGAPB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RALGAPB Q86X10 GOPC Homo sapiens Q9HD26-2
Y2H Prey Pooling
32296183
Intra
RALGAPB Q86X10 GOPC Homo sapiens Q9HD26-2
Validated Y2H
32296183
Intra
RALGAPB Q86X10 GOPC Homo sapiens Q9HD26-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tubulinopathy

  • Tubulinopathies
Septooptic Dysplasia

  • Septo-Optic Dysplasia

  • De Morsier Syndrome

  • Growth Hormone Deficiency With Pituitary Anomalies

  • SOD

  • Pituitary Hormone Deficiency, Combined, 5

  • Septo-Optic Dysplasia Spectrum

  • Septo-Optic Dysplasia With Growth Hormone Deficiency

  • Pituitary Hormone Deficiency, Combined 5

  • Hypopituitarism And Septooptic 'Dysplasia'

  • GHDPA

  • CPHD5

  • Dysplasia, Septo-Optic

  • Kallmann Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11632 RALGAPB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RALGAPB MGD MGI:2444531
Felis catus RALGAPB VGNC VGNC:64484
Canis familiaris RALGAPB VGNC VGNC:45334
Bos taurus RALGAPB VGNC VGNC:33703
Rattus norvegicus RALGAPB RGD RGD:1306861
Macaca mulatta RALGAPB VGNC VGNC:76562
Others RALGAPB NCBI