RALGAPB - Ral GTPase activating protein non-catalytic subunit beta Gene

Homo sapiens

Also known as KIAA1219; RalGAPbeta

Gene ID: 57148 | Gene type: protein coding

About RALGAPB

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,472,843-38,578,858 (from NCBI)

This gene has 9 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in thyroid (RPKM 11.6), testis (RPKM 11.5) and 25 other tissues.

Summary

Enables protein heterodimerization activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within Ral protein signal transduction; regulation of exocyst localization; and regulation of protein localization. [provided by Alliance of Genome Resources, Apr 2022]

RALGAPB Products(3)

mRNA	Protein	Name
NM_001282917.2	NP_001269846.1	ral GTPase-activating protein subunit beta isoform 1
NM_001282918.2	NP_001269847.1	ral GTPase-activating protein subunit beta isoform 2
NM_020336.4	NP_065069.1	ral GTPase-activating protein subunit beta isoform 1

Protein Preferred Names

Protein Names

ral GTPase-activating protein subunit beta

Ral GTPase activating protein non-catalytic beta subunit

Related Diseases

Diseases

Alias

Tubulinopathy

Tubulinopathies

Septooptic Dysplasia

Septo-Optic Dysplasia	De Morsier Syndrome
Growth Hormone Deficiency With Pituitary Anomalies	SOD
Pituitary Hormone Deficiency, Combined, 5	Septo-Optic Dysplasia Spectrum
Septo-Optic Dysplasia With Growth Hormone Deficiency	Pituitary Hormone Deficiency, Combined 5
Hypopituitarism And Septooptic 'Dysplasia'	GHDPA
CPHD5	Dysplasia, Septo-Optic
Kallmann Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11632	RALGAPB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RALGAPB	MGD	MGI:2444531
Felis catus	RALGAPB	VGNC	VGNC:64484
Canis familiaris	RALGAPB	VGNC	VGNC:45334
Bos taurus	RALGAPB	VGNC	VGNC:33703
Rattus norvegicus	RALGAPB	RGD	RGD:1306861
Macaca mulatta	RALGAPB	VGNC	VGNC:76562

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