NETO2 - neuropilin and tolloid like 2 Gene

Also Known as BTCL2; NEOT2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81831

About NETO2

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:47,077,703-47,143,945 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 35 paralogues. Broad expression in spleen (RPKM 8.8), brain (RPKM 6.7) and 17 other tissues.

Summary

This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating Kainate Receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

NETO2 Products (2)

mRNA Protein Name
NM_001201477.2 NP_001188406.1 neuropilin and tolloid-like protein 2 isoform 2 precursor
NM_018092.5 NP_060562.3 neuropilin and tolloid-like protein 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NETO2 Protein Structure

CUB

CUB: CUB domain (45 - 156)

CUB

CUB: CUB domain (181 - 287)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (296 - 331)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 525 a.a.
Protein Preferred Names Protein Names

neuropilin and tolloid-like protein 2

  • brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2

Related Diseases

Diseases Alias
Cataract 4, Multiple Types

  • Cataract 4 Multiple Types

  • CTRCT4

  • Cca3

  • Pcc

  • Aculeiform Cataract

  • Cataract 4, Multiple Types, With Or Without Microcornea

  • Cataract, Crystalline Aculeiform

  • Caca

  • Cataract, Congenital, Cerulean Type, 3

  • Congenital Cataract Cerulean Type 3

  • Cataract Congenital Dominant Non Nuclear

  • Ccp

  • Cataract, Nonnuclear Polymorphic Congenital

  • Cataract, Punctate, Progressive Juvenile-Onset

  • Cataract 4 Multiple Types With Or Without Microcornea

  • Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

  • Cataract, Polymorphic Congenital

  • Congenital Cataract Blue Dot Type 3

  • Congenital Non-Nuclear Polymorphic Cataract

  • Crystalline Aculeiform Cataract

  • Punctate, Progressive Juvenile-Onset, Cataract

  • Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS09214 NETO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NETO2 VGNC VGNC:43749
Bos taurus NETO2 VGNC VGNC:32012
Macaca mulatta NETO2 VGNC VGNC:99526
Rattus norvegicus NETO2 RGD RGD:1305310
Mus musculus NETO2 MGD MGI:1921763
Others NETO2 NCBI