JNJ-6204
Based on 1 Customer Validation
JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.60%
- CAS. Nr.: 2765264-50-2
- Formel: C19H11D6FN6O
- Molecular Weight:370.41
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
IC50: 2.3 nM (CSNK1D)[2]
JNJ-6204 inhibits CSNK1D in the BRET whole cell binding assay and in the PER2 translocation whole cell functional assay with IC50s of 72 nM and 542 nM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 2765264-50-2
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Unlabeled Cas 2765264-58-0
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Appearance Solid
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Molecular Weight 370.41
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Formel C19H11D6FN6O
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Color White to off-white
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SMILES
FC1=CC=C(N=C1)C2=NN3C(COC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C3)=C2C4=C5C(NN=C5)=NC=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (134.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6997 mL | 13.4986 mL | 26.9971 mL | 67.4928 mL |
| 5 mM | 0.5399 mL | 2.6997 mL | 5.3994 mL | 13.4986 mL | |
| 10 mM | 0.2700 mL | 1.3499 mL | 2.6997 mL | 6.7493 mL | |
| 15 mM | 0.1800 mL | 0.8999 mL | 1.7998 mL | 4.4995 mL | |
| 20 mM | 0.1350 mL | 0.6749 mL | 1.3499 mL | 3.3746 mL | |
| 25 mM | 0.1080 mL | 0.5399 mL | 1.0799 mL | 2.6997 mL | |
| 30 mM | 0.0900 mL | 0.4500 mL | 0.8999 mL | 2.2498 mL | |
| 40 mM | 0.0675 mL | 0.3375 mL | 0.6749 mL | 1.6873 mL | |
| 50 mM | 0.0540 mL | 0.2700 mL | 0.5399 mL | 1.3499 mL | |
| 60 mM | 0.0450 mL | 0.2250 mL | 0.4500 mL | 1.1249 mL | |
| 80 mM | 0.0337 mL | 0.1687 mL | 0.3375 mL | 0.8437 mL | |
| 100 mM | 0.0270 mL | 0.1350 mL | 0.2700 mL | 0.6749 mL |
JNJ-6204 Related Classifications
HY-148233S Related Classifications
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