Methyl tanshinonate
Methyl tanshinonate is a tanshinone, that can be isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae). Methyl tanshinonate is a potent inhibitor of Mpro enzyme in SARS-CoV (IC50 = 21.1 µM). Methyl tanshinonate can be used for diabetes and SARS-CoV research.
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- CAS. Nr.: 18887-19-9
- Formel: C20H18O5
- Molecular Weight:338.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AGS | IC50 |
>50 μM
Compound: 5, methyl tanshinonate
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Viability of human AGS cells under normoxic conditions after 24 hrs by MTT assay
Viability of human AGS cells under normoxic conditions after 24 hrs by MTT assay
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[PMID: 17583950] |
| AGS | IC50 |
7.48 μM
Compound: 5, methyl tanshinonate
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Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay
Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay
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[PMID: 17583950] |
| Hep 3B2 | IC50 |
>50 μM
Compound: 5, methyl tanshinonate
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Viability of human Hep3B cells under normoxic conditions after 24 hrs by MTT assay
Viability of human Hep3B cells under normoxic conditions after 24 hrs by MTT assay
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[PMID: 17583950] |
| Hep 3B2 | IC50 |
7.34 μM
Compound: 5, methyl tanshinonate
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Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay
Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay
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[PMID: 17583950] |
Chemical Information
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CAS. Nr. 18887-19-9
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Molecular Weight 338.35
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Formel C20H18O5
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SMILES
O=C1C2=C(CCC[C@]3(C)C(OC)=O)C3=CC=C2C4=C(C(C)=CO4)C1=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Kim DH, et al. Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B. Chem Biol Interact. 2017 Dec 25;278:65-73. [Content Brief]
[2]. Ni L, et al. Qualitative analysis of the roots of Salvia miltiorrhiza and Salvia yunnanensis based on NIR, UHPLC and LC-MS-MS. J Pharm Biomed Anal. 2019 Jun 5;170:295-304. [Content Brief]
[3]. Diniz LRL, et al. Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies. Biomolecules. 2021 Jan 7;11(1):74. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Methyl tanshinonate Related Classifications
HY-126416 Related Classifications
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