Cytotoxic and antibacterial activity of 2-oxopurine derivatives

  • Bioorg Med Chem Lett. 2002 Feb 25;12(4):567-9. doi: 10.1016/s0960-894x(01)00803-4.
Geir Andresen  1 ,  Lise-Lotte Gundersen ,  Jon Nissen-Meyer ,  Frode Rise ,  Bjørn Spilsberg
Affiliations
  • 1. Department of Chemistry, University of Oslo, PO Box 1033, Blindern, 0315 Oslo, Norway.
PMID: 11844673 DOI: 10.1016/s0960-894x(01)00803-4
Abstract

Initial screening of the cytotoxic and Antibacterial properties of 6-substituted 2-oxopurines and dihydro-2-oxopurines revealed that several compounds exhibited cytotoxicity against K-562 cells in the same range as the well known antileukemic drug 6-mercaptopurine. Most compounds were also tested for inhibitory effect on a Gram-positive bacterium, Lactobacillus casei, as well as the mycobacterium Mycobacterium tuberculosis. Generally the 2-oxopurines exhibited low Antibacterial effect.