Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei

  • Chem Commun (Camb). 2012 Jan 21;48(6):835-7. doi: 10.1039/c1cc16178d.
Peng-Yu Yang  1 ,  Min Wang ,  Cynthia Y He ,  Shao Q Yao
Affiliations
  • 1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
PMID: 22124229 DOI: 10.1039/c1cc16178d
Abstract

We report herein the design, synthesis and application of K11777-derived activity-based probes (ABPs) allowing in situ profiling and identification of potential cellular targets of K11777 in Trypanosoma brucei.

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