Sesquiterpenes from the Endophyte Glomerella cingulata

  • J Nat Prod. 2017 Oct 27;80(10):2609-2614. doi: 10.1021/acs.jnatprod.7b00054.
Yunbao Liu  1 ,  Yong Li  1 ,  Zhen Liu  1 ,  Li Li  1 ,  Jing Qu  1 ,  Shuanggang Ma  1 ,  Ridao Chen  1 ,  Jungui Dai  1 ,  Shishan Yu  1
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, China.
PMID: 29035525 DOI: 10.1021/acs.jnatprod.7b00054
Abstract

From the cultured endophytic fungus Glomerella cingulata isolated from a toxic plant, Gelsemium elegans, one new phenanthrene (1), four new Sesquiterpenes (2-5), and three known Sesquiterpenes (6-8) were isolated. Their structures were elucidated using spectroscopic methods. Based on the ECD calculations, the absolute configurations of the new compounds were determined. Compounds 2, 4, and 5 inhibited lipopolysaccharide (LPS)-induced NO production in BV2 cells by 50.6, 36.1, and 29.4%, respectively, at 1 μM (positive control curcumin, IC50 = 4.0 μM).