Effects of Dimethyl Phthalate (DMP) on Serum Sex Hormone Levels and Apoptosis in C57 Female Mice

  • Int J Endocrinol Metab. 2019 Apr 22;17(2):e82882. doi: 10.5812/ijem.82882.
Yue Mei  1 ,  Ma Rongshuang  1 ,  Zhang Ruizhi  1 ,  Huang Hongyuan  1 ,  Tan Qiyue  1 ,  Zhao Shuhua  1
Affiliations
  • 1. Jilin University School of Public Health, Changchun, China.
PMID: 31372171 DOI: 10.5812/ijem.82882
Abstract

Background: The effects of dimethyl phthalate (DMP) on the reproductive system of mammal females are unclear because no studies have been conducted on this topic.

Methods: In this study, 40 C57 female mice were used as experimental subjects and evenly divided into 8 groups, which were fed with mixed DMP (0, 0.5, 1, and 2 g/kg bw/day) and corn oil. After 20 days and 40 days of gavage, the mice were weighed and their individual ovary organ coefficients measured.

Results: Changes were discovered on progesterone, estradiol, follicle-stimulating hormone and luteinizing hormone in mouse serum, and on the Apoptosis rate of ovarian granulosa cells.

Conclusions: Prolonged exposure to DMP led to decreased secretion of FSH Hormones and increased secretion of E2 and LH Hormones. Furthermore, DMP interfered with the pituitary-ovary axis and increased the Apoptosis rate of ovarian granulosa cells. Therefore, prolonged exposure to DMP is likely to have negative effects on reproduction and development.

Keywords
Apoptosis; Dimethyl Phthalate; Endocrine Disruptors; Sex Hormone.
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