Effects of Chitosan on Drug Load and Release for Cisplatin-Hydroxyapatite-Gelatin Composite Microspheres
- Polymers (Basel). 2025 May 27;17(11):1485. doi: 10.3390/polym17111485.
- 1. Department of Materials Science and Engineering, National Chung Hsing University, Taichung 402, Taiwan.
- 2. Department of Orthopedics, Taichung Armed Forces General Hospital, Taichung 404, Taiwan.
- 3. Department of Gerontological Health Care, Central Taiwan University of Science and Technology, Taichung 406, Taiwan.
- 4. Department of Natural Biotechnology, Nanhua University, Chiayi 622, Taiwan.
- 5. Department of Dental Technology and Material Science, Central Taiwan University of Science and Technology, Taichung 406, Taiwan.
Cisplatin, a widely used chemotherapeutic agent, is limited by its poor bioavailability, rapid systemic clearance, and severe side effects. To overcome these limitations, hydroxyapatite-gelatin composite microspheres were developed to improve drug entrapment efficiency (DEE) and provide sustained drug release. Various formulations were prepared by incorporating chitosan either by mixing once or through a sequential coating strategy. By adjusting the loading procedure, the DEE increased from 58% to 99%. The composite microsphere effectively controlled the total drug release duration, extending it from one month to over 5 months. Moreover, the MTT assay demonstrated that all samples effectively inhibited cell growth, with cell viability reduced to less than 20% after 2 weeks of experimentation. These findings demonstrate that the sequential chitosan coating method offers superior drug entrapment and prolonged release compared to mixing chitosan once, exhibiting its potential as a sustained drug delivery system for Cancer treatment.
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Cat. No.Product NameDescriptionTargetResearch Area
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Research Areas: Cancer