Phenazoviridin, a novel free radical scavenger from Streptomyces sp. Taxonomy, fermentation, isolation, structure elucidation and biological properties

  • J Antibiot (Tokyo). 1993 Oct;46(10):1485-93. doi: 10.7164/antibiotics.46.1485.
S Kato  1 ,  K Shindo ,  Y Yamagishi ,  M Matsuoka ,  H Kawai ,  J Mochizuki
Affiliations
  • 1. Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
PMID: 8244877 DOI: 10.7164/antibiotics.46.1485
Abstract

Phenazoviridin is a newly discovered free radical scavenger from Microorganisms. It was isolated from the culture of Streptomyces sp. HR04. The structure of phenazoviridin was determined as 6-(3-methyl-2-butenyl)phenazine-1-carboxylic acid 6-deoxy-alpha-L-talopyranose ester on the basis of its spectroscopic and physico-chemical properties. The novel substance showed strong inhibitory activity against lipid peroxidation in rat brain homogenate and exhibited antihypoxic activity in mice.

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