The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis

  • J Bacteriol. 1999 Feb;181(4):1348-51. doi: 10.1128/JB.181.4.1348-1351.1999.
Y Ohashi  1 ,  Y Chijiiwa ,  K Suzuki ,  K Takahashi ,  H Nanamiya ,  T Sato ,  Y Hosoya ,  K Ochi ,  F Kawamura
Affiliations
  • 1. Laboratory of Molecular Genetics, College of Science, Rikkyo (St. Paul's) University, Toshima-ku, Tokyo 171-8501, Japan.
PMID: 9973366 DOI: 10.1128/JB.181.4.1348-1351.1999
Abstract

3-Methoxybenzamide (3-MBA), which is known to be an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. Our genetic analysis of 3-MBA-resistant mutants indicated that the primary target of the drug is the cell division system involving FtsZ function during both vegetative growth and sporulation.

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