(Rac)-Metyrapol
Metyrapol is a steroid 11β-hydroxylase inhibitor. Metyrapol blocks the conversion of deoxycorticosterone to corticosterone in rat adrenal homogenates. Metyrapol can be used in the study of metabolic diseases.
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- CAS. Nr.: 17159-42-1
- Formel: C14H16N2O
- Molecular Weight:228.29
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Racemic metyrapol (0.4 mM; 10 min preincubation, 5 min incubation), (-)-metyrapol, and (+)-metyrapol exhibit similar inhibitory activity on steroid 11β-hydroxylase in rat adrenal homogenates, with racemic metyrapol showing 40.8% inhibition at 0.4 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, 200-250 g)[1]
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Dosage:0.1 mmol/kg; 0.25 mmol/kg; 0.5 mmol/kg
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Administration:i.v.; single dose
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Result:Recorded AUC of (-)-MOH as 0.50±0.03 mM·h, CL as 0.10±0.01 l/h·kg, and Vss as 0.63±0.15 l/kg after 0.1 mmol/kg dose.
Recorded AUC of (+)-MOH as 0.42±0.03 mM·h, CL as 0.11±0.01 l/h·kg, and Vss as 0.74±0.15 l/kg after 0.1 mmol/kg dose.
Recorded AUC of (-)-MOH as 1.41±0.33 mM·h, CL as 0.09±0.01 l/h·kg, and Vss as 0.64±0.10 l/kg after 0.25 mmol/kg dose.
Recorded AUC of (+)-MOH as 1.11±0.04 mM·h, CL as 0.11±0.01 l/h·kg, and Vss as 0.62±0.10 l/kg after 0.25 mmol/kg dose.
Recorded AUC of (-)-MOH as 2.78±0.66 mM·h, CL as 0.09±0.02 l/h·kg, and Vss as 0.53±0.06 l/kg after 0.5 mmol/kg dose.
Recorded AUC of (+)-MOH as 2.75±0.40 mM·h, CL as 0.09±0.01 l/h·kg, and Vss as 0.55±0.05 l/kg after 0.5 mmol/kg dose.
Detected insignificant formation of metyrapone from metyrapol in rat plasma.
Chemical Information
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CAS. Nr. 17159-42-1
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Molecular Weight 228.29
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Formel C14H16N2O
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SMILES
CC(C)(C(O)C1=CC=CN=C1)C2=CC=CN=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(Rac)-Metyrapol Related Classifications
HY-123273 Related Classifications
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