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Art. -Nr.: HY-107489R

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RO 4938581 (Standard)

RO 4938581 (Standard) is the analytical standard of RO 4938581 (HY-107489). This product is intended for research and analytical applications. RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a K_i of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (K_i, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 883093-10-5
Formel: C₁₃H₈BrF₂N₅
Molecular Weight:352.14

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

RO 4938581 (Standard) Chemical Structure

CAS. Nr.: 883093-10-5

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Ki: 4.6 nM (GABA_A α5β3γ2a), 174 nM (GABA_A α1β3γ2a), 185 nM (GABA_A α2β3γ2a), 80 nM (GABA_A α3β3γ2a)^[1]

Chemical Information

CAS. Nr. 883093-10-5
Molecular Weight 352.14
Formel C₁₃H₈BrF₂N₅
SMILES

FC(C1=C2N(C3=CC=C(Br)C=C3C4=NC=NN4C2)C=N1)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Knust H, et al. The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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