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Zifcasiran

(Synonyms: ADS-007; ARO HIF2)

Zifcasiran (ADS-007; ARO HIF2) is an siRNA synthetic double-stranded RNAi trigger. Zifcasiran sodium selectively target hypoxia-inducible factor-2α (HIF2α) interrupting downstream pro-oncogenic signaling in clear cell renal cell carcinoma (ccRCC). Zifcasiran sodium engages the cell's RNAi machinery to target HIF2α (EPAS1) mRNA for degradation, thereby reducing the amount of free HIF2α mRNA available for translation.

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  • CAS. Nr.: 2437257-11-7
  • Formel: C737H972F20N211O349P43S8
  • Molecular Weight:20339.13
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Zifcasiran Chemical Structure
    Zifcasiran Chemical Structure
CAS. Nr.: 2437257-11-7
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Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen

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  • Zifcasiran Chemical Structure
    Zifcasiran Chemical Structure RNA, (Cm-sp-Am-Am-Cm-Gm-Um-Am-Am-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-Um-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]U-Cm-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]G-Am-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-
    1/16
  • RNA, (Cm-sp-Am-Am-Cm-Gm-Um-Am-Am-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-Um-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]U-Cm-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Um-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]G-Am-[2′-O-[[1-[2-[2-[2-[2-[2-fluoro-4-[(1S)-3-hydroxy-3-oxo-1-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]propyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methyl]]A-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-