ARPP19 - cAMP regulated phosphoprotein 19 Gene

Also Known as ENSAL; ARPP16; ARPP-16; ARPP-19

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10776

About ARPP19

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:52,547,045-52,569,446 (from NCBI)

This gene has 13 transcripts (splice variants), 193 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 79.8), thyroid (RPKM 29.3) and 24 other tissues.

Summary

The 19-kD cAMP-regulated phosphoprotein plays a role in regulating Mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]

ARPP19 Products (5)

mRNA Protein Name
NM_001306191.2 NP_001293120.1 cAMP-regulated phosphoprotein 19 isoform 1
NM_001306195.1 NP_001293124.1 cAMP-regulated phosphoprotein 19 isoform 2
NM_001306196.2 NP_001293125.1 cAMP-regulated phosphoprotein 19 isoform 1
NM_001330309.2 NP_001317238.1 cAMP-regulated phosphoprotein 19 isoform 3
NM_006628.6 NP_006619.1 cAMP-regulated phosphoprotein 19 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables potassium channel regulator activity IDA
IDA: Inferred from direct assay
9653196 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein phosphatase 2A binding EXP
EXP: Inferred from Experiment
38123684 GOA
enables protein phosphatase 2A binding IDA
IDA: Inferred from direct assay
38123684 GOA
enables protein phosphatase 2A binding IMP
IMP: Inferred from mutant phenotype
38123684 GOA
enables protein phosphatase inhibitor activity IDA
IDA: Inferred from direct assay
38123684 GOA
enables protein phosphatase inhibitor activity IMP
IMP: Inferred from mutant phenotype
38123684 GOA
enables signaling receptor binding IDA
IDA: Inferred from direct assay
9653196 GOA
Biological Process GO Annotation Evidence References Source
involved in G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
21164014 GOA
involved in mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
21164014 GOA
involved in positive regulation of gluconeogenesis IDA
IDA: Inferred from direct assay
9653196 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARPP19 Protein Structure

Endosulfine

Endosulfine: cAMP-regulated phosphoprotein/endosulfine conserved region (22 - 79)

  • 0
  • 100
  • 112 a.a.
Protein Preferred Names Protein Names

cAMP-regulated phosphoprotein 19

  • cAMP-regulated phosphoprotein 19kDa

ARPP19 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARPP19 P56211 SPDYC Homo sapiens Q5MJ68
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations

  • MCCCHCM
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01025 ARPP19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARPP19 VGNC VGNC:38133
Felis catus ARPP19 VGNC VGNC:104359
Bos taurus ARPP19 VGNC VGNC:26167
Mus musculus ARPP19 MGD MGI:1891691
Rattus norvegicus ARPP19 RGD RGD:71054
Others ARPP19 NCBI