Bad - BCL2-associated agonist of cell death Gene

Also Known as Bbc2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12015

Summary

Enables cysteine-type endopeptidase activator activity involved in apoptotic process and protein Phosphatase binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of Glucokinase activity; and positive regulation of mitochondrial membrane potential. Acts upstream of or within several processes, including apoptotic signaling pathway; modulation by virus of host apoptotic process; and positive regulation of lymphocyte differentiation. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic Cancer. Orthologous to human BAD (BCL2 associated agonist of cell death). [provided by Alliance of Genome Resources, Apr 2022]

Bad Products (2)

mRNA Protein Name
NM_001285453.1 NP_001272382.1 bcl2-associated agonist of cell death isoform 2
NM_007522.3 NP_031548.1 bcl2-associated agonist of cell death isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
IDA: Inferred from direct assay
19915011 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7834748 MGI
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
12944463 MGI
Biological Process GO Annotation Evidence References Source
involved in ADP metabolic process IMP
IMP: Inferred from mutant phenotype
18223655 MGI
involved in ATP metabolic process IMP
IMP: Inferred from mutant phenotype
18223655 MGI
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
19915011 MGI
acts upstream of or within apoptotic signaling pathway IDA
IDA: Inferred from direct assay
11717309 MGI
acts upstream of or within apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
12931191 MGI
involved in cellular response to lipid IEP
IEP: Inferred from expression pattern
18223655 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
14967141 MGI
acts upstream of or within epithelial cell proliferation IDA
IDA: Inferred from direct assay
9176392 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
12115603 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IGI
IGI: Inferred from genetic interaction
12431371 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
14967141 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
12431371 MGI
acts upstream of or within glucose catabolic process IMP
IMP: Inferred from mutant phenotype
12931191 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
12931191 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
18223655 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IDA
IDA: Inferred from direct assay
15231831 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
12431371 MGI
acts upstream of or within positive regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
12431371 MGI
acts upstream of or within positive regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
12431371 MGI
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
21095239 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
18223655 MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
18223655 MGI
involved in positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IDA
IDA: Inferred from direct assay
21716255 MGI
involved in positive regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
18223655 MGI
involved in positive regulation of type B pancreatic cell development IMP
IMP: Inferred from mutant phenotype
18223655 MGI
acts upstream of or within regulation of apoptotic process IDA
IDA: Inferred from direct assay
7834748 MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
14967141 MGI
acts upstream of or within release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
12431371 MGI
acts upstream of or within symbiont-mediated activation of host apoptosis IDA
IDA: Inferred from direct assay
15231831 MGI
acts upstream of or within symbiont-mediated suppression of host apoptosis IDA
IDA: Inferred from direct assay
15231831 MGI
acts upstream of or within symbiont-mediated suppression of host apoptosis IMP
IMP: Inferred from mutant phenotype
15231831 MGI
involved in type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
18223655 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11146504 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11980919 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
12931191 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bcl2-associated agonist of cell death

  • bcl-2-binding component 6

  • bcl-xL/Bcl-2-associated death promoter

  • bcl2 antagonist of cell death

Bad Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Bad Q61337 BCL2L1 Homo sapiens Q07817-1
Anti Tag CoIP
15694340
Cross
Bad Q61337 YWHAZ Homo sapiens P63104
Pull Down
11723239
Intra
Bad Q61337 Bcl2l1 Mus musculus Q64373-1
Anti Bait CoIP
23332762
Cross
Bad Q61337 BCL2 Homo sapiens P10415
Anti Tag CoIP
15694340
Cross
Bad Q61337 BCL2 Homo sapiens P10415
FPS
16697956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13495 ML281 Degrader 98.04% Unkown
HY-N1983 Caudatin 99.95% Unkown
HY-180190 Tubulin polymerization-IN-85 / Unkown
HY-182937 FLC-8 Modulator / Unkown
HY-180948 PZ-11 / Unkown
HY-181599 XAN-5 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bad NCBI NCBI:572