FGF6 - fibroblast growth factor 6 Gene

Also Known as HST2; HBGF-6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2251

About FGF6

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,434,142-4,445,815 (from NCBI)

This gene has 3 transcripts (splice variants), 269 orthologues and 21 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]

FGF6 Products (1)

mRNA Protein Name
NM_020996.3 NP_066276.2 fibroblast growth factor 6 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
8663044 GOA
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
8663044 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGF6 Protein Structure

FGF

FGF: Fibroblast growth factor (84 - 205)

  • 0
  • 100
  • 208 a.a.
Protein Preferred Names Protein Names

fibroblast growth factor 6

  • FGF-6

FGF6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FGF6 P10767 NCALD Homo sapiens P61601
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FGF6 Proteins

Cat. No. Product Name Accession Purity
HY-P7174 FGF-6 Protein, Human P10767 (G41-I208) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700068AF Animal-Free FGF-6 Protein, Human (His) P10767 (G41-I208) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Apert Syndrome

  • Acrocephalosyndactyly Type I

  • Acs1

  • Acrocephalosyndactylia

  • Acrocephalosyndactyly

  • Acs I

  • Apert-Crouzon Disease

  • Acrocephalosyndactyly Type 1

  • Acrocephalosyndactyly, Type I

  • Acs 1

  • Acrocephalo-Syndactyly Type 1

  • Syndactylic Oxycephaly

  • Apert'S Syndrome

  • Type I Acrocephalosyndactyly

  • APRS
Nasal Cavity Adenocarcinoma

  • Adenocarcinoma Of Nasal Cavity

  • Adenocarcinoma Of The Nasal Cavity
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04904 FGF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174694 Human FGF6 mRNA / Unkown
HY-RS19328 Fgf6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25819 Fgf6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FGF6 MGD MGI:95520
Felis catus FGF6 VGNC VGNC:62254
Canis familiaris FGF6 VGNC VGNC:40852
Bos taurus FGF6 VGNC VGNC:28981
Rattus norvegicus FGF6 RGD RGD:620130
Macaca mulatta FGF6 VGNC VGNC:108343
Others FGF6 NCBI