Corin - corin, serine peptidase Gene

Also Known as Lrp4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53419

Summary

Enables serine-type endopeptidase activity. Involved in several processes, including peptide hormone processing; regulation of renal sodium excretion; and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Located in cell surface. Is expressed in several structures, including floor plate; heart; lip; phalanx; and skin. Human ortholog(s) of this gene implicated in hypertension and pre-eclampsia. Orthologous to human CORIN (corin, serine peptidase). [provided by Alliance of Genome Resources, Apr 2022]

Corin Products (2)

mRNA Protein Name
NM_001122756.1 NP_001116228.1 atrial natriuretic peptide-converting enzyme isoform 2
NM_016869.3 NP_058565.2 atrial natriuretic peptide-converting enzyme isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables serine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
11884416 MGI
Biological Process GO Annotation Evidence References Source
involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
22437503 MGI
involved in peptide hormone processing IMP
IMP: Inferred from mutant phenotype
11884416 MGI
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
22418978 MGI
involved in regulation of renal sodium excretion IMP
IMP: Inferred from mutant phenotype
22418978 MGI
involved in regulation of systemic arterial blood pressure by atrial natriuretic peptide IMP
IMP: Inferred from mutant phenotype
15637153 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
17670789 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

atrial natriuretic peptide-converting enzyme

  • low density lipoprotein receptor-related protein 4

  • low density lipoprotein-related protein 4

  • pro-ANP-converting enzyme

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111048 Corin Inhibitor 98.16% Unkown
HY-RS03047 CORIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17975 Corin Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24446 Corin Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Corin NCBI NCBI:10699