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SDK2 - sidekick cell adhesion molecule 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54549

About SDK2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:73,334,384-73,644,445 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 36 paralogues. Biased expression in testis (RPKM 6.4), spleen (RPKM 1.7) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined. [provided by RefSeq, Jul 2008]

SDK2 Products (1)

mRNA	Protein	Name
NM_001144952.2	NP_001138424.1	protein sidekick-2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDK2 Protein Structure

I-set

Ig_2

I-set

fn3

0
400
800
1200
1600
2000
2172 a.a.

Protein Preferred Names	Protein Names
protein sidekick-2	sidekick homolog 2

SDK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SDK2	Q58EX2	VMAC	Homo sapiens	Q2NL98	Y2H Prey Pooling	32296183
Intra	SDK2	Q58EX2	VMAC	Homo sapiens	Q2NL98	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Patellar Tendinitis	Patellar Tendonitis
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Brachyolmia	Brachyrachia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12596	SDK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SDK2	VGNC	VGNC:64954
Mus musculus	SDK2	MGD	MGI:2443847
Macaca mulatta	SDK2	VGNC	VGNC:99225
Rattus norvegicus	SDK2	RGD	RGD:1310397
Canis familiaris	SDK2	VGNC	VGNC:45954
Bos taurus	SDK2	VGNC	VGNC:34394
Others	SDK2	NCBI