NRP2 - neuropilin 2 Gene

Also Known as NP2; NPN2; PRO2714; VEGF165R2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8828

About NRP2

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:205,682,501-205,798,131 (from NCBI)

This gene has 17 transcripts (splice variants), 285 orthologues and 35 paralogues. Broad expression in placenta (RPKM 10.6), ovary (RPKM 9.8) and 20 other tissues.

Summary

This gene encodes a member of the neuropilin family of Receptor Proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Jul 2021]

NRP2 Products (6)

mRNA Protein Name
NM_003872.3 NP_003863.2 neuropilin-2 isoform 2 precursor
NM_018534.4 NP_061004.3 neuropilin-2 isoform 4 precursor
NM_201264.2 NP_957716.1 neuropilin-2 isoform 6 precursor
NM_201266.2 NP_957718.1 neuropilin-2 isoform 1 precursor
NM_201267.2 NP_957719.1 neuropilin-2 isoform 5 precursor
NM_201279.2 NP_958436.1 neuropilin-2 isoform 3 precursor

NRP2 Protein Structure

CUB

CUB: CUB domain (28 - 139)

CUB

CUB: CUB domain (149 - 264)

F5_F8_type_C

F5_F8_type_C: F5/8 type C domain (292 - 424)

F5_F8_type_C

F5_F8_type_C: F5/8 type C domain (449 - 589)

MAM

MAM: MAM domain, meprin/A5/mu (646 - 800)

DUF3481

DUF3481: C-terminal domain of neuropilin glycoprotein (861 - 928)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 931 a.a.
Protein Preferred Names Protein Names

neuropilin-2

  • neuropilin-2a(17)

NRP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
NRP2 O60462 Vegfc Mus musculus P97953-1
Solid Phase Assay
25752543
Cross
NRP2 O60462 Vegfc Mus musculus P97953-1
TSA
25752543
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NRP2 Proteins

Cat. No. Product Name Accession Purity
HY-P73313 Neuropilin-2 Protein, Human (HEK293, Fc) O60462-3/NP_003863.2 (Q23-Y855) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73314 Neuropilin-2 Protein, Human (HEK293, His) O60462-3/NP_003863.2 (Q23-P859) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Lymphangioma

  • Lymphatic Malformation

  • Lymphatic Malformations

  • Benign Lymphangioma

  • Congenital Lymphangioma

  • Lymphangiomas
Wallerian Degeneration

  • Wallerian Degeneration Of The Pyramidal Tract
Covid-19

  • 2019 Novel Coronavirus

  • 2019-Ncov Infection

  • Covid19

  • Sars-Cov-2 Infection

  • Wuhan Coronavirus Infection

  • Wuhan Seafood Market Pneumonia Virus Infection
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Hereditary Lymphedema

  • Milroy Disease
Hereditary Lymphedema I

  • Lymphedema

  • Hereditary Lymphedema Type I

  • Congenital Primary Lymphedema

  • Lmph1

  • Milroy Disease

  • Nonne-Milroy Lymphedema

  • Pcl

  • Lymphedema Hereditary Type 1
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990782 Efzofitimod 99.29% Phase 3

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11647A RPARPAR acetate Ligand 99.47% Unkown
HY-NP223 PLGF-2 Protein, human / Unkown
HY-P11647 RPARPAR Ligand / Unkown
HY-RS09205 NELL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09580 NRP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17411 Nrp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23865 Nrp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992280 Anti-NRP2 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NRP2 RGD RGD:621442
Bos taurus NRP2 VGNC VGNC:32267
Mus musculus NRP2 MGD MGI:1100492
Canis familiaris NRP2 VGNC VGNC:43975
Macaca mulatta NRP2 VGNC VGNC:75533
Felis catus NRP2 VGNC VGNC:68570
Others NRP2 NCBI