PAPSS1 - 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Gene

Also Known as SK1; PAPSS; ATPSK1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9061

About PAPSS1

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:107,613,666-107,720,234 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 32.6), brain (RPKM 30.3) and 25 other tissues.

Summary

Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) Enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and Other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]

PAPSS1 Products (1)

mRNA Protein Name
NM_005443.5 NP_005434.4 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables adenylylsulfate kinase activity IDA
IDA: Inferred from direct assay
14747722 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
14747722 GOA
enables sulfate adenylyltransferase (ATP) activity IDA
IDA: Inferred from direct assay
14747722 GOA
Biological Process GO Annotation Evidence References Source
involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IDA
IDA: Inferred from direct assay
14747722 GOA
involved in sulfate assimilation IDA
IDA: Inferred from direct assay
14747722 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAPSS1 Protein Structure

APS_kinase

APS_kinase: Adenylylsulphate kinase (51 - 207)

PUA_2

PUA_2: PUA-like domain (232 - 385)

ATP-sulfurylase

ATP-sulfurylase: ATP-sulfurylase (394 - 618)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 624 a.a.
Protein Preferred Names Protein Names

bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

  • 3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1

PAPSS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PAPSS1 O43252 PAPSS2 Homo sapiens O95340
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Achondrogenesis, Type Ib

  • ACG1B

  • Achondrogenesis Type Ib

  • Achondrogenesis Type 1b

  • Achondrogenesis Ib

  • Achondrogenesis Fraccaro Type

  • Achondrogenesis, Fraccaro Type

  • Achondrogenesis, Parenti-Fraccaro Type

  • Achondrogenesis 1b

  • Acg-Ib

  • Fraccaro Achondrogenesis
Spondyloepiphyseal Dysplasia With Congenital Joint Dislocations

  • Spondyloepiphyseal Dysplasia

  • Chst3-Related Skeletal Dysplasia

  • Humerospinal Dysostosis

  • Spondyloepiphyseal Dysplasia, Omani Type

  • Chondrodysplasia With Multiple Dislocations

  • SEDCJD

  • Hsd

  • Cdmd

  • Humero-Spinal Dysostosis

  • Kozlowski Celermajer Tink Syndrome

  • Chondrodysplasia With Congenital Joint Dislocations, Chst3 Type

  • Larsen Syndrome, Recessive Type

  • Humero-Spinal Dysostosis With Congenital Heart Disease

  • Omani Type

  • Sed

  • Chst3 Deficiency

  • Chst3-Related Dysplasia

  • Recessive Larsen Syndrome

  • Autosomal Recessive Larsen Syndrome

  • Sed With Luxations, Chst3 Type

  • Sed, Omani Type

  • Sdcd, Chst3 Type

  • Spondyloepiphyseal Dysplasia With Congenital Joint Dyslocations, Chst3 Type

  • Sed Omani Type

  • Spondyloepiphyseal Dysplasia Omani Type

  • Larsen Syndrome, Autosomal Recessive

  • Mucopolysaccharidosis Iv

  • Spondyloepiphyseal Dysplasia, Congenita
Cortisone Reductase Deficiency

  • 11-Alpha Beta-Hydroxysteroid Dehydrogenase Type I Deficiency Of

  • Cortrd

  • Hsd 11b1 Deficiency
Brachyolmia

  • Brachyrachia
Atelosteogenesis

  • Atelosteogenesis, Type 1
Spondyloepimetaphyseal Dysplasia

  • Dysplasia, Spondyloepimetaphyseal
Large Congenital Melanocytic Nevus

  • Giant Pigmented Hairy Nevus

  • Giant Congenital Melanocytic Nevus

  • Gmn

  • Congenital Pigmented Nevus

  • Lcmn

  • Gphn

  • Giant Congenital Nevus

  • Bathing Trunk Nevus

  • Congenital Giant Pigmented Nevus

  • Congenital Hairy Nevus

  • Giant Hairy Nevus

  • Giant Pigmented Nevus

  • Congenital Giant Pigmented Nevus Of Skin

  • Congenital Melanocytic Nevus Syndrome

  • Giant Congenital Melanocytic Nevi

  • Giant Congenital Pigmented Nevus

  • Melanocytic Nevus Syndrome, Congenital
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10030 PAPSS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PAPSS1 RGD RGD:1308081
Felis catus PAPSS1 VGNC VGNC:68693
Bos taurus PAPSS1 VGNC VGNC:53770
Macaca mulatta PAPSS1 VGNC VGNC:75757
Canis familiaris PAPSS1 VGNC VGNC:44258
Mus musculus PAPSS1 MGD MGI:1330587
Others PAPSS1 NCBI