PAPSS1 - 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Gene

Homo sapiens

Also known as SK1; PAPSS; ATPSK1

Gene ID: 9061 | Gene type: protein coding

About PAPSS1

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:107,613,666-107,720,234 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 32.6), brain (RPKM 30.3) and 25 other tissues.

Summary

Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]

PAPSS1 Products(1)

mRNA	Protein	Name
NM_005443.5	NP_005434.4	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

PAPSS1 Protein Structure

APS_kinase

PUA_2

ATP-sulfurylase

0
100
200
300
400
500
624 a.a.

Protein Preferred Names

Protein Names

bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1

Recombinant PAPSS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71027	PAPSS1 Protein, Human (HEK293, His)	O43252 (M1-A624)	≥95%

Related Diseases

Diseases

Alias

Achondrogenesis, Type Ib

ACG1B	Achondrogenesis Type Ib
Achondrogenesis Type 1b	Achondrogenesis Ib
Achondrogenesis Fraccaro Type	Achondrogenesis, Fraccaro Type
Achondrogenesis, Parenti-Fraccaro Type	Achondrogenesis 1b
Acg-Ib	Fraccaro Achondrogenesis

Spondyloepiphyseal Dysplasia With Congenital Joint Dislocations

Spondyloepiphyseal Dysplasia	Chst3-Related Skeletal Dysplasia
Humerospinal Dysostosis	Spondyloepiphyseal Dysplasia, Omani Type
Chondrodysplasia With Multiple Dislocations	SEDCJD
Hsd	Cdmd
Humero-Spinal Dysostosis	Kozlowski Celermajer Tink Syndrome
Chondrodysplasia With Congenital Joint Dislocations, Chst3 Type	Larsen Syndrome, Recessive Type
Humero-Spinal Dysostosis With Congenital Heart Disease	Omani Type
Sed	Chst3 Deficiency
Chst3-Related Dysplasia	Recessive Larsen Syndrome
Autosomal Recessive Larsen Syndrome	Sed With Luxations, Chst3 Type
Sed, Omani Type	Sdcd, Chst3 Type
Spondyloepiphyseal Dysplasia With Congenital Joint Dyslocations, Chst3 Type	Sed Omani Type
Spondyloepiphyseal Dysplasia Omani Type	Larsen Syndrome, Autosomal Recessive
Mucopolysaccharidosis Iv	Spondyloepiphyseal Dysplasia, Congenita

Cortisone Reductase Deficiency

11-Alpha Beta-Hydroxysteroid Dehydrogenase Type I Deficiency Of	Cortrd
Hsd 11b1 Deficiency

Brachyolmia

Brachyrachia

Atelosteogenesis

Atelosteogenesis, Type 1

Spondyloepimetaphyseal Dysplasia

Dysplasia, Spondyloepimetaphyseal

Large Congenital Melanocytic Nevus

Giant Pigmented Hairy Nevus	Giant Congenital Melanocytic Nevus
Gmn	Congenital Pigmented Nevus
Lcmn	Gphn
Giant Congenital Nevus	Bathing Trunk Nevus
Congenital Giant Pigmented Nevus	Congenital Hairy Nevus
Giant Hairy Nevus	Giant Pigmented Nevus
Congenital Giant Pigmented Nevus Of Skin	Congenital Melanocytic Nevus Syndrome
Giant Congenital Melanocytic Nevi	Giant Congenital Pigmented Nevus
Melanocytic Nevus Syndrome, Congenital

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10030	PAPSS1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PAPSS1	RGD	RGD:1308081
Felis catus	PAPSS1	VGNC	VGNC:68693
Bos taurus	PAPSS1	VGNC	VGNC:53770
Macaca mulatta	PAPSS1	VGNC	VGNC:75757
Canis familiaris	PAPSS1	VGNC	VGNC:44258
Mus musculus	PAPSS1	MGD	MGI:1330587

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