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Cat. No.: HY-13829

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BMS-585248

BMS-585248 is a potent, third-generation HIV-1 attachment inhibitor with a promising initial in vitro and in vivo pharmacokinetic profile.

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CAS No.: 619331-12-3
Formule: C₂₂H₁₈FN₇O₃
Masse moléculaire:447.42

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

BMS-585248 Chemical Structure

CAS No.: 619331-12-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

BMS-585248 is a potent, third-generation HIV-1 attachment inhibitor with a promising initial in vitro and in vivo pharmacokinetic profile^[1].

IC₅₀ & Target

HIV-1

Voir tous les produits spécifiques à Isoform HIV :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	CC₅₀	>300 μM Compound: 12m, BMS-585428	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 23360431]
MT2	EC₅₀	0.8 nM Compound: 12m, BMS-585428	Antiviral activity against HIV1 BRU infected in MT2 cells after 4 to 5 days by reverse transcriptase assay in absence of human serum Antiviral activity against HIV1 BRU infected in MT2 cells after 4 to 5 days by reverse transcriptase assay in absence of human serum	[PMID: 23360431]
MT2	EC₅₀	0.87 nM Compound: 12m, BMS-585428	Antiviral activity against X4-tropic HIV1 LAI infected in MT2 cells Antiviral activity against X4-tropic HIV1 LAI infected in MT2 cells	[PMID: 23360431]
MT2	EC₅₀	1.32 nM Compound: 12m, BMS-585428	Antiviral activity against X4-tropic HIV1 NL4-3 infected in MT2 cells Antiviral activity against X4-tropic HIV1 NL4-3 infected in MT2 cells	[PMID: 23360431]
MT2	EC₅₀	2.3 nM Compound: 12m, BMS-585428	Antiviral activity against HIV1 BRU infected in MT2 cells after 4 to 5 days by reverse transcriptase assay in presence of human serum Antiviral activity against HIV1 BRU infected in MT2 cells after 4 to 5 days by reverse transcriptase assay in presence of human serum	[PMID: 23360431]
MT2	EC₅₀	5.17 nM Compound: 12m, BMS-585428	Antiviral activity against X4-tropic HIV1 MN infected in MT2 cells Antiviral activity against X4-tropic HIV1 MN infected in MT2 cells	[PMID: 23360431]
U-87MG ATCC	IC₅₀	<5 nM Compound: 29	Antiviral activity against HIV1 pseudovirus in U87 cells expressing CD4 and CCR5 after 72 hrs by M33 pseudotyped assay Antiviral activity against HIV1 pseudovirus in U87 cells expressing CD4 and CCR5 after 72 hrs by M33 pseudotyped assay	[PMID: 18052117]
U-87MG ATCC	CC₅₀	>40000 nM Compound: 29	Cytotoxicity against human U87 cells expressing CD4 and CXCR4 Cytotoxicity against human U87 cells expressing CD4 and CXCR4	[PMID: 18052117]
U-87MG ATCC	CC₅₀	>40000 nM Compound: 3	Cytotoxicity against human U87 cells coexpressing CD4, CxCR4 receptors after 72 hrs Cytotoxicity against human U87 cells coexpressing CD4, CxCR4 receptors after 72 hrs	[PMID: 19534463]

In Vivo

BMS-585248 (intravenous (1 mg/kg) and oral (5-200 mg/kg); once) has a good pharmacokinetic profile, with AUC values of 3220 nM·h and 8064 nM·h after IV (1 mg/kg) and oral (5 mg/kg) administration in male rats, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male rats^[1]
Dosage:

5, 15, and 200 mg/kg
Administration:

Orally, once (Pharmacokinetic Analysis)
Result:

Pharmacokinetic Parameters of BMS-585248 in male rats^[1].

PO

Dose (mg/kg) 15 75 200

C_max (μM) 6.6 8.4 11

AUC_tot (μM·h) 42 115 145

Chemical Information

CAS No. 619331-12-3
Masse moléculaire 447.42
Formule C₂₂H₁₈FN₇O₃
SMILES

O=C(N1CCN(C(C2=CC=CC=C2)=O)CC1)C(C3=CNC4=C3C(F)=CN=C4N5N=NC=C5)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Regueiro-Ren A, et al. Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 13. Synthesis and profiling of a novel amminium prodrug of the HIV-1 attachment inhibitor BMS-585248. J Med Chem. 2013 Feb 28;56(4):1670-6. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

	PO
Dose (mg/kg)	15	75	200
C_max (μM)	6.6	8.4	11
AUC_tot (μM·h)	42	115	145

BMS-585248

Voir tous les produits spécifiques à Isoform HIV

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

BMS-585248 Related Classifications

HY-13829 Related Classifications