GPA33 - glycoprotein A33 Gene

Also Known as A33

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10223

About GPA33

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:167,052,836-167,090,377 (from NCBI)

This gene has 4 transcripts (splice variants), 232 orthologues and 14 paralogues. Biased expression in colon (RPKM 108.1), duodenum (RPKM 69.2) and 2 other tissues.

Summary

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]

GPA33 Products (1)

mRNA Protein Name
NM_005814.3 NP_005805.1 cell surface A33 antigen precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPA33 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (22 - 129)

Ig_2

Ig_2: Immunoglobulin domain (154 - 228)

  • 0
  • 100
  • 200
  • 300
  • 319 a.a.
Protein Preferred Names Protein Names

cell surface A33 antigen

  • glycoprotein A33 (transmembrane)

GPA33 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
GPA33 Q99795 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
Intra
GPA33 Q99795 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GPA33 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P70899 GPA33 Protein, Human (HEK293, His) Q99795 (I22-V235) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78136 GPA33 Protein, Human (Biotinylated, HEK293, His-Avi) Q99795 (I22-V235) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78450 GPA33 Protein, Human (HEK293, His-Avi) Q99795 (I22-V235) ≥ 95%, as determined by Bis-Tris PAGE.

GPA33 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P82521 GPA33 Antibody (YA2266) WB, IHC-P, IP Human

Related Diseases

Diseases Alias
Foodborne Botulism

  • Botulism

  • Botulism Poisoning

  • Intoxication With Clostridium Botulinum Toxin

  • Wound Botulism

  • Food Poisoning Due To Clostridium Botulinum

  • Infection Due To Clostridium Botulinum

  • Infant Botulism

  • Intoxication Botulism

  • Botulism, Infantile

  • Clostridium Botulinum Poisoning

  • Botulism Nos
Wound Botulism

  • Cutaneous Infectious Botulism

  • Cutaneous Toxin-Mediated Botulism

  • Inoculation Botulism

  • Skin Infectious Botulism

  • Skin Toxin-Mediated Botulism
Intestinal Botulism

  • Intestinal Colonization Botulism

  • Intestinal Toxemia Botulism

  • Intestinal Toxin-Mediated Botulism
Infant Botulism

  • Infant Intestinal Botulism

  • Infant Intestinal Toxemia Botulism

  • Infant Intestinal Toxin-Mediated Botulism

  • Infantile Botulism

  • Botulism, Infantile
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Nom du produit Effect
Pureté Phase
HY-P990611 KRN-330 / Phase 2
HY-P991188 MGD007 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS05613 GPA33 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18066 Gpa33 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24541 Gpa33 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GPA33 VGNC VGNC:50186
Felis catus GPA33 VGNC VGNC:67400
Macaca mulatta GPA33 VGNC VGNC:106374
Canis familiaris GPA33 VGNC VGNC:53485
Mus musculus GPA33 MGD MGI:1891703
Rattus norvegicus GPA33 RGD RGD:1306711
Others GPA33 NCBI