Bmp10 - bone morphogenetic protein 10 Gene

Also Known as b2b2711Clo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12154

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. Homozygous knockout mice for this gene exhibit impaired heart development and embryonic lethality. [provided by RefSeq, Aug 2016]

Bmp10 Products (1)

mRNA Protein Name
NM_009756.3 NP_033886.2 bone morphogenetic protein 10 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Références Source
involved in BMP signaling pathway IDA
IDA: Inferred from direct assay
16798733 MGI
involved in adult heart development IMP
IMP: Inferred from mutant phenotype
16798733 MGI
involved in atrial cardiac muscle tissue morphogenesis IEP
IEP: Inferred from expression pattern
10072785 MGI
involved in cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
15073151 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
15073151 MGI
involved in heart trabecula formation IMP
IMP: Inferred from mutant phenotype
15073151 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
27002738 MGI
involved in negative regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
16798733 MGI
involved in positive regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
16798733 MGI
involved in positive regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17336907 MGI
involved in positive regulation of cartilage development IDA
IDA: Inferred from direct assay
19956691 MGI
involved in positive regulation of cell proliferation involved in heart morphogenesis IGI
IGI: Inferred from genetic interaction
17336907 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
22783020 MGI
involved in ventricular cardiac muscle cell development IDA
IDA: Inferred from direct assay
16798733 MGI
involved in ventricular cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
15073151 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bone morphogenetic protein 10

  • BMP-10

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS01534 BMP10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174781 Human ACVRL1 mRNA / Unkown
HY-RS19175 Bmp10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25664 Bmp10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmp10 NCBI NCBI:27302