BMP10 - bone morphogenetic protein 10 Gene
Species: Homo sapiens
About BMP10
This gene has 1 transcript (splice variant), 274 orthologues and 31 paralogues. Restricted expression toward heart (RPKM 211.3).
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016]
BMP10 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_014482.3 | NP_055297.1 | bone morphogenetic protein 10 preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables growth factor activity |
IDA
IDA: Inferred from direct assay
|
19903896 | GOA |
| enables hormone activity |
IDA
IDA: Inferred from direct assay
|
17921333 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
17068149 | GOA |
| enables receptor serine/threonine kinase binding |
IDA
IDA: Inferred from direct assay
|
17068149 | GOA |
| enables telethonin binding |
IPI
IPI: Inferred from physical interaction
|
17921333 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in Z disc |
IDA
IDA: Inferred from direct assay
|
17921333 | GOA |
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
17921333 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
17921333 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
17921333 | GOA |
BMP10 Protein Structure
TGFb_propeptide: TGF-beta propeptide (49 - 256)
TGF_beta: Transforming growth factor beta like domain (321 - 424)
- 0
- 100
- 200
- 300
- 400
- 424 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
bone morphogenetic protein 10 |
|
BMP10 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
BMP10 | O95393 | JAGN1 | Homo sapiens | Q8N5M9 | 32296183 | |
|
Intra
|
BMP10 | O95393 | JAGN1 | Homo sapiens | Q8N5M9 | 32296183 | |
|
Intra
|
BMP10 | O95393 | JAGN1 | Homo sapiens | Q8N5M9 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CISD2 | Homo sapiens | Q8N5K1 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CISD2 | Homo sapiens | Q8N5K1 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CISD2 | Homo sapiens | Q8N5K1 | 32296183 | |
|
Intra
|
BMP10 | O95393 | PLPP4 | Homo sapiens | Q5VZY2 | 32296183 | |
|
Intra
|
BMP10 | O95393 | PLPP4 | Homo sapiens | Q5VZY2 | 32296183 | |
|
Intra
|
BMP10 | O95393 | PLPP4 | Homo sapiens | Q5VZY2 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SPAG4 | Homo sapiens | Q9NPE6 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SPAG4 | Homo sapiens | Q9NPE6 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SPAG4 | Homo sapiens | Q9NPE6 | 32296183 | |
|
Intra
|
BMP10 | O95393 | LRRC25 | Homo sapiens | Q8N386 | 32296183 | |
|
Intra
|
BMP10 | O95393 | LRRC25 | Homo sapiens | Q8N386 | 32296183 | |
|
Intra
|
BMP10 | O95393 | LRRC25 | Homo sapiens | Q8N386 | 32296183 | |
|
Intra
|
BMP10 | O95393 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
BMP10 | O95393 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
BMP10 | O95393 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
BMP10 | O95393 | BSCL2 | Homo sapiens | J3KQ12 | 32296183 | |
|
Intra
|
BMP10 | O95393 | BSCL2 | Homo sapiens | J3KQ12 | 32296183 | |
|
Intra
|
BMP10 | O95393 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
BMP10 | O95393 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
BMP10 | O95393 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FNDC9 | Homo sapiens | Q8TBE3 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FNDC9 | Homo sapiens | Q8TBE3 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FNDC9 | Homo sapiens | Q8TBE3 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TMPRSS2 | Homo sapiens | O15393-2 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TMPRSS2 | Homo sapiens | O15393-2 | 32296183 | |
|
Intra
|
BMP10 | O95393 | MS4A3 | Homo sapiens | Q96HJ5 | 32296183 | |
|
Intra
|
BMP10 | O95393 | MS4A3 | Homo sapiens | Q96HJ5 | 32296183 | |
|
Intra
|
BMP10 | O95393 | MS4A3 | Homo sapiens | Q96HJ5 | 32296183 | |
|
Intra
|
BMP10 | O95393 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
BMP10 | O95393 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
BMP10 | O95393 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TNFSF8 | Homo sapiens | P32971 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TNFSF8 | Homo sapiens | P32971 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TNFSF8 | Homo sapiens | P32971 | 32296183 | |
|
Intra
|
BMP10 | O95393 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
BMP10 | O95393 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
BMP10 | O95393 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
BMP10 | O95393 | GJB1 | Homo sapiens | P08034 | 32296183 | |
|
Intra
|
BMP10 | O95393 | GJB1 | Homo sapiens | P08034 | 32296183 | |
|
Intra
|
BMP10 | O95393 | IL3RA | Homo sapiens | P26951 | 32296183 | |
|
Intra
|
BMP10 | O95393 | IL3RA | Homo sapiens | P26951 | 32296183 | |
|
Intra
|
BMP10 | O95393 | IL3RA | Homo sapiens | P26951 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TSPAN31 | Homo sapiens | Q12999 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TSPAN31 | Homo sapiens | Q12999 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TSPAN31 | Homo sapiens | Q12999 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TMEM86B | Homo sapiens | Q8N661 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TMEM86B | Homo sapiens | Q8N661 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TMEM86B | Homo sapiens | Q8N661 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FFAR2 | Homo sapiens | O15552 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FFAR2 | Homo sapiens | O15552 | 32296183 | |
|
Intra
|
BMP10 | O95393 | GGT6 | Homo sapiens | Q6P531 | 32296183 | |
|
Intra
|
BMP10 | O95393 | GGT6 | Homo sapiens | Q6P531 | 32296183 | |
|
Intra
|
BMP10 | O95393 | GGT6 | Homo sapiens | Q6P531 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FCGR1A | Homo sapiens | P12314 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FCGR1A | Homo sapiens | P12314 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FCGR1A | Homo sapiens | P12314 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CD33 | Homo sapiens | P20138 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CD33 | Homo sapiens | P20138 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CD33 | Homo sapiens | P20138 | 32296183 | |
|
Intra
|
BMP10 | O95393 | KIR3DL1 | Homo sapiens | P43629 | 32296183 | |
|
Intra
|
BMP10 | O95393 | KIR3DL1 | Homo sapiens | P43629 | 32296183 | |
|
Intra
|
BMP10 | O95393 | KIR3DL1 | Homo sapiens | P43629 | 32296183 | |
|
Intra
|
BMP10 | O95393 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
BMP10 | O95393 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
BMP10 | O95393 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FKBP7 | Homo sapiens | Q9Y680 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FKBP7 | Homo sapiens | Q9Y680 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FKBP7 | Homo sapiens | Q9Y680 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC10A1 | Homo sapiens | Q14973 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC10A1 | Homo sapiens | Q14973 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC10A1 | Homo sapiens | Q14973 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TMEM45B | Homo sapiens | Q96B21 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TMEM45B | Homo sapiens | Q96B21 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TMEM45B | Homo sapiens | Q96B21 | 32296183 | |
|
Intra
|
BMP10 | O95393 | MTIF3 | Homo sapiens | Q9H2K0 | 32296183 | |
|
Intra
|
BMP10 | O95393 | MTIF3 | Homo sapiens | Q9H2K0 | 32296183 | |
|
Intra
|
BMP10 | O95393 | MTIF3 | Homo sapiens | Q9H2K0 | 32296183 | |
|
Intra
|
BMP10 | O95393 | LRRC4C | Homo sapiens | Q9HCJ2 | 32296183 | |
|
Intra
|
BMP10 | O95393 | LRRC4C | Homo sapiens | Q9HCJ2 | 32296183 | |
|
Intra
|
BMP10 | O95393 | LRRC4C | Homo sapiens | Q9HCJ2 | 32296183 | |
|
Intra
|
BMP10 | O95393 | APOA5 | Homo sapiens | Q6Q788 | 32296183 | |
|
Intra
|
BMP10 | O95393 | APOA5 | Homo sapiens | Q6Q788 | 32296183 | |
|
Intra
|
BMP10 | O95393 | APOA5 | Homo sapiens | Q6Q788 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FCRL4 | Homo sapiens | Q96PJ5 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FCRL4 | Homo sapiens | Q96PJ5 | 32296183 | |
|
Intra
|
BMP10 | O95393 | FCRL4 | Homo sapiens | Q96PJ5 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TNFSF14 | Homo sapiens | O43557 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TNFSF14 | Homo sapiens | O43557 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TCTA | Homo sapiens | P57738 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TCTA | Homo sapiens | P57738 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TCTA | Homo sapiens | P57738 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CCDC70 | Homo sapiens | Q6NSX1 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CCDC70 | Homo sapiens | Q6NSX1 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CCDC70 | Homo sapiens | Q6NSX1 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SIT1 | Homo sapiens | Q9Y3P8 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SIT1 | Homo sapiens | Q9Y3P8 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SIT1 | Homo sapiens | Q9Y3P8 | 32296183 | |
|
Intra
|
BMP10 | O95393 | BIK | Homo sapiens | Q13323 | 32296183 | |
|
Intra
|
BMP10 | O95393 | BIK | Homo sapiens | Q13323 | 32296183 | |
|
Intra
|
BMP10 | O95393 | BIK | Homo sapiens | Q13323 | 32296183 | |
|
Intra
|
BMP10 | O95393 | DEXI | Homo sapiens | O95424 | 32296183 | |
|
Intra
|
BMP10 | O95393 | DEXI | Homo sapiens | O95424 | 32296183 | |
|
Intra
|
BMP10 | O95393 | DEXI | Homo sapiens | O95424 | 32296183 | |
|
Intra
|
BMP10 | O95393 | COQ9 | Homo sapiens | O75208 | 32296183 | |
|
Intra
|
BMP10 | O95393 | COQ9 | Homo sapiens | O75208 | 32296183 | |
|
Intra
|
BMP10 | O95393 | MGST3 | Homo sapiens | O14880 | 32296183 | |
|
Intra
|
BMP10 | O95393 | MGST3 | Homo sapiens | O14880 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CLDN7 | Homo sapiens | O95471 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CLDN7 | Homo sapiens | O95471 | 32296183 | |
|
Intra
|
BMP10 | O95393 | CLDN7 | Homo sapiens | O95471 | 32296183 | |
|
Intra
|
BMP10 | O95393 | VSIR | Homo sapiens | Q9H7M9 | 32296183 | |
|
Intra
|
BMP10 | O95393 | VSIR | Homo sapiens | Q9H7M9 | 32296183 | |
|
Intra
|
BMP10 | O95393 | VSIR | Homo sapiens | Q9H7M9 | 32296183 | |
|
Intra
|
BMP10 | O95393 | MRPS18B | Homo sapiens | Q9Y676 | 32296183 | |
|
Intra
|
BMP10 | O95393 | MRPS18B | Homo sapiens | Q9Y676 | 32296183 | |
|
Intra
|
BMP10 | O95393 | MRPS18B | Homo sapiens | Q9Y676 | 32296183 | |
|
Intra
|
BMP10 | O95393 | REEP4 | Homo sapiens | Q9H6H4 | 32296183 | |
|
Intra
|
BMP10 | O95393 | REEP4 | Homo sapiens | Q9H6H4 | 32296183 | |
|
Intra
|
BMP10 | O95393 | REEP4 | Homo sapiens | Q9H6H4 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC4A1 | Homo sapiens | P02730 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC4A1 | Homo sapiens | P02730 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC4A1 | Homo sapiens | P02730 | 32296183 | |
|
Intra
|
BMP10 | O95393 | BSND | Homo sapiens | Q8WZ55 | 32296183 | |
|
Intra
|
BMP10 | O95393 | BSND | Homo sapiens | Q8WZ55 | 32296183 | |
|
Intra
|
BMP10 | O95393 | BSND | Homo sapiens | Q8WZ55 | 32296183 | |
|
Intra
|
BMP10 | O95393 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
BMP10 | O95393 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
BMP10 | O95393 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
BMP10 | O95393 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
BMP10 | O95393 | KLRC1 | Homo sapiens | P26715 | 32296183 | |
|
Intra
|
BMP10 | O95393 | KLRC1 | Homo sapiens | P26715 | 32296183 | |
|
Intra
|
BMP10 | O95393 | KLRC1 | Homo sapiens | P26715 | 32296183 | |
|
Intra
|
BMP10 | O95393 | ERP29 | Homo sapiens | P30040 | 32296183 | |
|
Intra
|
BMP10 | O95393 | ERP29 | Homo sapiens | P30040 | 32296183 | |
|
Intra
|
BMP10 | O95393 | ERP29 | Homo sapiens | P30040 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC38A1 | Homo sapiens | Q9H2H9 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC38A1 | Homo sapiens | Q9H2H9 | 32296183 | |
|
Intra
|
BMP10 | O95393 | SLC38A1 | Homo sapiens | Q9H2H9 | 32296183 |
Recombinant BMP10 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P700019AF | Animal-Free BMP-10 Protein, Human (His) | O95393 (N317-R424) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Myostatin-Related Muscle Hypertrophy |
|
|
| Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome |
|
|
| Pulmonary Hypertension |
|
|
| Arteriovenous Malformation |
|
|
| Right Atrial Isomerism |
|
|
| Telangiectasis |
|
|
| Breast Cancer |
|
|
| Acromesomelic Dysplasia 2a |
|
|
| Hereditary Hemorrhagic Telangiectasia |
|
|
| Double Outlet Right Ventricle |
|
|
| Heart Septal Defect |
|
|
| Atrioventricular Septal Defect |
|
|
| Ventricular Septal Defect |
|
|
| Left Ventricular Noncompaction |
|
|
| Aortic Valve Disease 1 |
|
|
| Atrial Heart Septal Defect |
|
|
| Tetralogy Of Fallot |
|
|
| Dilated Cardiomyopathy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | BMP10 | RGD | RGD:1562986 |
| Mus musculus | BMP10 | MGD | MGI:1338820 |
| Bos taurus | BMP10 | VGNC | VGNC:26515 |
| Canis familiaris | BMP10 | VGNC | VGNC:38476 |
| Macaca mulatta | BMP10 | VGNC | VGNC:70354 |
| Others | BMP10 | NCBI |