SLC4A1 - solute carrier family 4 member 1 (Diego blood group) Gene

Also Known as DI; FR; SW; WD; WR; AE1; CHC; SAO; WD1; BND3; EPB3; SPH4; CD233; EMPB3; RTA1A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6521

About SLC4A1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,248,390-44,268,135 (from NCBI)

This gene has 4 transcripts (splice variants), 279 orthologues, 9 paralogues and is associated with 20 phenotypes. Restricted expression toward bone marrow (RPKM 157.0).

Summary

The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds Carbonic Anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq, Jul 2008]

SLC4A1 Products (1)

mRNA	Protein	Name
NM_000342.4	NP_000333.1	band 3 anion transport protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ankyrin binding	IPI IPI: Inferred from physical interaction	379653	GOA
enables bicarbonate transmembrane transporter activity	IDA IDA: Inferred from direct assay	24121512	GOA
enables chloride:bicarbonate antiporter activity	IDA IDA: Inferred from direct assay	28387307	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	2204832	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	379653	GOA
enables solute:inorganic anion antiporter activity	IDA IDA: Inferred from direct assay	14734552	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in bicarbonate transport	IDA IDA: Inferred from direct assay	24121512	GOA
involved in chloride transmembrane transport	IDA IDA: Inferred from direct assay	14734552	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ankyrin-1 complex	IDA IDA: Inferred from direct assay	35835865	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12539048	GOA
located in cortical cytoskeleton	IDA IDA: Inferred from direct assay	16669616	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	379653	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC4A1 Protein Structure

Band_3_cyto

HCO3_cotransp

0
200
400
600
800
911 a.a.

Protein Preferred Names	Protein Names
band 3 anion transport protein	Diego blood group

SLC4A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC4A1	P02730	ADAM33	Homo sapiens	Q08AM2	Validated Y2H	32296183
Intra	SLC4A1	P02730	CFHR5	Homo sapiens	Q9BXR6	Validated Y2H	32296183
Intra	SLC4A1	P02730	STOM	Homo sapiens	P27105	Density Sedimentation	23219802
Intra	SLC4A1	P02730	STOM	Homo sapiens	P27105	Crosslink	23219802
Intra	SLC4A1	P02730	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	SLC4A1	P02730	GYPA	Homo sapiens	P02724	Density Sedimentation	23219802
Intra	SLC4A1	P02730	ATP1B1	Homo sapiens	P05026	ELISA	25012180
Intra	SLC4A1	P02730	ATP1B1	Homo sapiens	P05026	Anti Bait CoIP	25012180
Intra	SLC4A1	P02730	ATP1B1	Homo sapiens	P05026	Confocal	25012180
Intra	SLC4A1	P02730	ATP1B1	Homo sapiens	P05026	Fluorescence Spectr	25012180

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC4A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82074	Band 3 Antibody (YA1819)	WB, IHC-P, ICC/IF	Human

Related Diseases

Diseases	Alias
Renal Tubular Acidosis, Distal, 1	Autosomal Dominant Distal Renal Tubular Acidosis DRTA1 Rta, Distal Type, Autosomal Dominant Renal Tubular Acidosis I Rta, Classic Type Rta, Gradient Type Distal Renal Tubular Acidosis 1 Autosomal Dominant Slc4a1-Associated Distal Renal Tubular Acidosis Renal Tubular Acidosis 1 Ad Drta Autosomal Dominant Rta Distal Type Rta Classic Type Rta Gradient Type Renal Tubular Acidosis, Distal, Autosomal Dominant Acidosis, Tubular, Renal, Distal, Autosomal Dominant Distal Renal Tubular Acidosis
Cryohydrocytosis	CHC Stomatocytosis, Cold-Sensitive Hereditary Cryohydrocytosis With Normal Stomatin Pseudohyperkalemia Cardiff
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia	DRTA4 Renal Tubular Acidosis, Distal, With Normal Red Cell Morphology Distal Renal Tubular Acidosis 4 With Hemolytic Anemia Distal Renal Tubular Acidosis With Anemia Drta With Anemia Autosomal Recessive Distal Rta With Hemolytic Anemia DRTA-NRC
Ovalocytosis, Southeast Asian	Southeast Asian Ovalocytosis SAO Elliptocytosis 4 Ovalocytosis, Malaysian-Melanesian-Filipino Type El4 Elliptocytosis, Stomatocytic Hereditary He, Stomatocytic Ovalocytosis, Sa Type Hereditary Ovalocytosis Melanesian Elliptocytosis Melanesian Ovalocytosis Stomatocytic Elliptocytosis Elliptocytosis, Hereditary
Spherocytosis, Type 4	Hereditary Spherocytosis Type 4 SPH4 Hs4 Spherocytosis, Hereditary, 4 Hereditary Spherocytosis 4 Spherocytosis 4
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Blood Group, Diego System	DI Diego Blood Group System Blood Group--Diego System
Blood Group--Swann System	SW
Blood Group--Wright Antigen	WR Wright Blood Group Antigen
Renal Tubular Acidosis	Acidosis Renal Tubular Acidosis, Renal Tubular Lightwood-Albright Syndrome Lightwood Syndrome Idiopathic Infantile Hypercalcemia - Mild Form Kidney Tubular Acidosis Renal Tubule Acidosis Kidney Acidosis Renal Acidosis Renal Hyperchloremic Acidosis Rta - [Renal Tubular Acidosis]
Distal Renal Tubular Acidosis	Classic Rta Familial Distal Primary Acidosis Renal Tubular Acidosis Type 1 Drta Renal Tubular Acidosis, Distal
Distal Renal Tubular Acidosis With Hemolytic Anemia	Renal Tubular Acidosis, Distal, With Hemolytic Anemia Acidosis, Tubular, Renal, Distal, With Hemolytic Anemia
Pseudohyperkalemia, Familial, 2, Due To Red Cell Leak	Pseudohyperkalemia Cardiff Familial Pseudohyperkalemia PSHK2 Pseudohyperkalemia Lille Pseudohyperkalemia Falkirk Pseudohyperkalemia Chiswick Pseudohyperkalemia East London Cryohydrocytosis, Mild Cryohydrocytosis Stomatocytosis, Cold-Sensitive
Hereditary Spherocytosis	Congenital Spherocytic Hemolytic Anemia Spherocytic Anemia Congenital Spherocytosis Spherocytosis, Type 1 Minkowski Chauffard Syndrome Hs Minkowski-Chauffard Disease Minkowski-Chauffard Syndrome Spherocytosis Hereditary Spherocytosis, Hereditary Anemia, Hereditary Spherocytic Hemolytic
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema	Dehydrated Hereditary Stomatocytosis Hereditary Xerocytosis Xerocytosis, Hereditary Pshk1 Pseudohyperkalemia Edinburgh Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema DHS1 Dhs Hereditary Desiccytosis Dehydrated Hereditary Stomatocytosis 1 Desiccytosis, Hereditary Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak Pseudohyperkalemia Familial 1, Due To Red Cell Leak Desiccytosis Hereditary Xerocytosis Hereditary Familial Pseudohyperkalemia 1 Due To Red Cell Leak Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema Xerocytosis
Renal Tubular Acidosis, Distal, 3, With Or Without Sensorineural Hearing Loss	Autosomal Recessive Distal Renal Tubular Acidosis Autosomal Recessive Distal Rta Renal Tubular Acidosis, Distal, Autosomal Recessive DRTA3 Rtadr Ar Drta Distal Renal Tubular Acidosis 3, With Or Without Sensorineural Hearing Loss Renal Tubular Acidosis, Distal, Autosomal Recessive, With Late-Onset Sensorineural Hearing Loss, Included Rta, Distal, Autosomal Recessive Renal Tubular Acidosis, Autosomal Recessive With Preserved Hearing Distal Renal Tubular Acidosis With Late-Onset Sensorineural Hearing Loss Distal Renal Tubular Acidosis With Preserved Hearing Acidosis, Tubular, Renal, Distal, Autosomal Recessive
Nephrocalcinosis	Hypercalcemic Nephropathy
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Hereditary Elliptocytosis	Congenital Elliptocytosis Ovalocytosis Elliptocytosis, Hereditary He Elliptocytosis Hereditary Congenital Ovalocytosis Elliptocytosis Hereditary Elliptocytosis With Infantile Poikilocytosis Hereditary Ovalocytosis Oval Erythrocytosis He - [Hereditary Elliptocytosis] Elliptocytosis Anaemia
Blood Group Incompatibility
Metabolic Acidosis
Kernicterus	Bilirubin Encephalopathy Hyperbilirubinemic Encephalopathy Kernicterus Spectrum Disorder
Tetanus Neonatorum	Neonatal Tetanus NNT Trismus Neonatorum Newborn Trismus
Corneal Endothelial Dystrophy	Congenital Hereditary Endothelial Dystrophy Of Cornea Chandler Syndrome CHED Chandler'S Syndrome Endothelial Corneal Dystrophy Ched2 Maumenee Corneal Dystrophy Corneal Dystrophy, Congenital Hereditary Endothelial Dystrophy Of Corneal Endothelium Corneal Endothelial Dystrophy 2 Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly Ched2, Formerly Corneal Endothelial Dystrophy, Autosomal Recessive Endothelial Dystrophy Posterior Membrane Corneal Dystrophy Corneal Endothelial Dystrophy Type 2 Congenital Hereditary Endothelial Dystrophy Of The Cornea Congenital Hereditary Endothelial Dystrophy Type Ii Autosomal Recessive Ched Autosomal Recessive Congenital Hereditary Endothelial Dystrophy Chedii Congenital Hereditary Endothelial Dystrophy Type 2 Infantile Hereditary Endothelial Dystrophy Congenital Hereditary Endothelial Corneal Dystrophy Corneal Endothelial Dystrophy 2, Autosomal Recessive Iridocorneal Endothelial Syndrome Dystrophy, Corneal, Endothelial Corneal Endothelial Dystrophy 1, Autosomal Dominant
Priapism	Mentulagra Priapism, Familial Idiopathic Familial Idiopathic Priapism Pathologic Erection Painful Erection
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Respiratory Disease Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Congenital Dyserythropoietic Anemia	Congenital Dyshaematopoietic Anaemia Dyserythropoietic Anemia, Congenital Cda Anemia, Dyserythropoietic, Congenital Anemia Dyserythropoietic Congenital Cda - [Congenital Dyserythropoietic Anaemia] Dyserythropoietic Dyshaematopoietic Congenital Anaemia Dyshaematopoietic Anaemia Dyserythropoietic Anaemia
Corneal Dystrophy And Perceptive Deafness	Corneal Dystrophy-Perceptive Deafness Syndrome CDPD Harboyan Syndrome Cdpd1 Corneal Dystrophy And Sensorineural Deafness Corneal Endothelial Dystrophy And Perceptive Deafness Corneal Dystrophy With Progressive Deafness Congenital Corneal Dystrophy, Progressive Sensorineural Deafness Corneal Dystrophy With Progressive Hearing Loss Corneal Dystrophy-Perceptive Hearing Loss Syndrome Dystrophy, Corneal, Endothelial, And Perceptive Deafness
Thalassemia	Sickle-Cell Thalassemia With Crisis Sickle-Cell Thalassemia Without Crisis Thalassemia Hb-S Disease With Crisis Thalassemia Hb-S Disease Without Crisis Thalassemias Hereditary Leptocytosis Haemoglobin Thalassaemia Disorder Thalassaemia Syndrome Thalassaemia Nos Thalassemia Variants
Pendred Syndrome	Goiter-Deafness Syndrome Deafness With Goiter PDS Thyroid Dyshormonogenesis 2b Tdh2b Autosomal Recessive Sensorineural Hearing Impairment And Goiter Pendred'S Syndrome Thyroid Hormonogenesis, Genetic Defect In, 2b Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b Congenital Hypothyroidism Due To Dyshormonogenesis 2b Genetic Defect In Thyroid Hormonogenesis 2b Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter Goiter-Hearing Loss Syndrome Goitre-Deafness Syndrome Goitre Deafness
Glutamate-Cysteine Ligase Deficiency	Gamma-Glutamylcysteine Synthetase Deficiency Hemolytic Anemia Due To Gamma-Glutamylcysteine Synthetase Deficiency Gamma-Glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To
Plasmodium Falciparum Malaria	Falciparum Malaria Malaria, Falciparum Malaria Fever, Subtertian Malignant Tertian Fever Malaria Falciparum Cerebral Malaria Nos Cerebral Malaria
Nephrolithiasis	Kidney Stones Stone - Kidney/Ureter Kidney Calculi
Rift Valley Fever	Rfv - [Rift Valley Fever]
Renal Tubular Transport Disease	Renal Tubular Transport, Inborn Errors Inborn Renal Tubular Transport Disorder
Osteopetrosis, Autosomal Recessive 3	Osteopetrosis With Renal Tubular Acidosis Marble Brain Disease OPTB3 Guibaud-Vainsel Syndrome Carbonic Anhydrase Ii Deficiency Osteopetrosis, Autosomal Recessive 3, With Renal Tubular Acidosis Autosomal Recessive Osteopetrosis 3 Carbonic Anhydrase 2 Deficiency Autosomal Recessive Osteopetrosis 3 With Renal Tubular Acidosis Osteopetrosis Autosomal Recessive 3 Autosomal Recessive Osteopetrosis Type 3 Guibaud Vainsel Syndrome Mixed Rta Mixed Renal Tubular Acidosis Renal Tubular Acidosis Type 3 Carbonic Anhydrase Ii Deficiency Syndrome Carbonic Anhydrase Ii Variant Osteopetrosis, Autosomal Recessive, Type 3 Carbonic Anhydrase 2
Overhydrated Hereditary Stomatocytosis	Ohs Potassium Sodium Disorder Of Erythrocyte OHST Stomatocytosis I Potassium-Sodium Disorder Of Erythrocyte Stomatocytosisiohst Hereditary, Overhydrated, Cation-Leak Stomatocytosis Overhydrated Cation Leak Stomatocytosis Stomatocytosis, Overhydrated Hereditary
Beta-Thalassemia	Beta Thalassemia Cooley'S Anemia Mediterranean Anemia Beta Thalassemia Intermedia Erythroblastic Anemia Thalassemia, Hispanic Gamma-Delta-Beta Thalassemia Major Thalassemia Minor Beta-Plus-Thalassemia Thalassemia, Beta Beta Thalassemia Major Beta Thalassemia Minor Thalassemias, Beta- Microcytemia, Beta Type Thalassemia, Beta Type B-THAL Mediterranean Anaemia Beta Thalassaemia Syndrome Mediterranean Disease Beta Thalassaemia Disease
Splenomegaly
Osteopetrosis, Autosomal Recessive 6	OPTB6 Autosomal Recessive Osteopetrosis 6 Autosomal Recessive Osteopetrosis Intermediate Form Osteopetrosis, Autosomal Recessive, Intermediate Form Osteopetrosis Autosomal Recessive 6 Autosomal Recessive Osteopetrosis Type 6 Osteopetrosis Autosomal Recessive Intermediate Form Intermediate Osteopetrosis Autosomal Recessive Intermediate Osteopetrosis Osteopetrosis, Autosomal Recessive, Type 6
Congenital Hemolytic Anemia	Anemia Hemolytic Congenital Anemia, Hemolytic, Congenital Congenital Hemolytic Anaemia Hereditary Hemolytic Anaemia Hereditary Hemolytic Anemia
Hypogonadotropic Hypogonadism 2 With Or Without Anosmia	Kallmann Syndrome 2 Kal2 HH2 Hypogonadism, Hypogonadotropic, Type 2 With/Without Anosmia
Amelanotic Melanoma	Melanoma, Amelanotic Melanoma Amelanotic Amelanotic Skin Melanoma
Glucosephosphate Dehydrogenase Deficiency	G6pd Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency Deficiency Of Glucose-6-Phosphate Dehydrogenase Glucose 6 Phosphate Dehydrogenase Deficiency Deficiency Of G-6pd G6pdd
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Fuchs' Endothelial Dystrophy	Fuchs Endothelial Corneal Dystrophy Fuchs Endothelial Dystrophy Fuchs Dystrophy Fced Fuchs' Corneal Dystrophy Fuchs' Endothelial Corneal Dystrophy Fuchs Atrophy Fuchs Corneal Dystrophy Endoepithelial Corneal Dystrophy Fecd Late Hereditary Endothelial Dystrophy Corneal Dystrophy, Fuchs Endothelial Dystrophy, Corneal, Fuchs Endothelial Corneal Dystrophy, Fuchs' Endothelial, 1
Gilbert Syndrome	Gilbert Disease Gilbert'S Disease Gilbert'S Syndrome Cholemia, Familial Familial Nonhemolytic Jaundice Meulengracht Syndrome Gilbert Syndrome, Susceptibility To Hyperbilirubinemia, Gilbert Type Hblrg Hyperbilirubinemia, Arias Type Hyperbilirubinemia I Constitutional Hyperbilirubinemia Gilbert-Meulengracht Syndrome Hereditary Nonhemolytic Jaundice Hyperbilirubinemia Arias Type Hyperbilirubinemia Type 1 Constitutional Liver Dysfunction Gilbert-Lereboullet Syndrome Hyperbilirubinemia 1 Unconjugated Benign Bilirubinemia GILBS Gilberts Syndrome Familial Nonhaemolytic Jaundice Constitutional Hyperbilirubinaemia Hereditary Nonhaemolytic Bilirubinaemia Familial Nonhaemolytic Bilirubinaemia Idiopathic Hyperbilirubinaemia Icterus Intermittens Juvenilis Chronic Intermittent Juvenile Jaundice Low-Grade Chronic Hyperbilirubinaemia Syndrome Benign Unconjugated Bilirubinaemia Syndrome Hereditary Nonhaemolytic Jaundice Idiopathic Unconjugated Hyperbilirubinaemia Gilbert--Lereboullet Syndrome Constitutional Hepatic Dysfunction Meulengracht Icterus Cholaemia Familiaris Simplex Familial Cholaemia Congenital Familial Cholaemia Physiologic Cholaemia Hyperbilirubinaemia Type 1 Gilbert Cholaemia
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13265	SLC4A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20193	Slc4a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26698	Slc4a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC4A1	VGNC	VGNC:49095
Bos taurus	SLC4A1	VGNC	VGNC:55870
Macaca mulatta	SLC4A1	VGNC	VGNC:99259
Rattus norvegicus	SLC4A1	RGD	RGD:3710
Felis catus	SLC4A1	VGNC	VGNC:99454
Mus musculus	SLC4A1	MGD	MGI:109393
Others	SLC4A1	NCBI