Plp1 - proteolipid protein 1 Gene

Also Known as Plp

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24943

Summary

A structural constituent of myelin sheath. Involved in several processes, including AMPA selective glutamate receptor signaling pathway; nervous system development; and positive regulation of calcium ion transmembrane transport. Located in myelin sheath. Part of Integrin alphav-beta3 complex. Used to study demyelinating disease and visual epilepsy. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Plp1 Products (1)

mRNA Protein Name
NM_030990.3 NP_112252.1 myelin proteolipid protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
16510724 RGD
enables structural constituent of myelin sheath IMP
IMP: Inferred from mutant phenotype
3476944 RGD
Biological Process GO Annotation Evidence Références Source
involved in AMPA selective glutamate receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16510724 RGD
involved in glial cell differentiation IMP
IMP: Inferred from mutant phenotype
1384273 RGD
involved in myelination IMP
IMP: Inferred from mutant phenotype
3476944 RGD
involved in positive regulation of calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
16510724 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
16510724 RGD
Cellular Component GO Annotation Evidence Références Source
part of integrin alphav-beta3 complex IDA
IDA: Inferred from direct assay
16510724 RGD
located in myelin sheath IDA
IDA: Inferred from direct assay
17960831 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myelin proteolipid protein

  • Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)

  • lipophilin

  • proteolipid protein (myelin) 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-128749A D-Glucaric acid tetrahydrate Inducer 99.87% Unkown
HY-RS10731 PLP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18783 Plp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25272 Plp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plp1 NCBI NCBI:5354