Cyp27a1 - cytochrome P450, family 27, subfamily a, polypeptide 1 Gene

Also Known as Cyp27; P450C27

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 301517

Summary

Enables HSP70 protein binding activity; Cholesterol 26-hydroxylase activity; and vitamin D3 25-hydroxylase activity. Involved in Cholesterol metabolic process. Located in mitochondrial inner membrane. Biomarker of extrahepatic cholestasis. Human ortholog(s) of this gene implicated in cerebrotendinous xanthomatosis. Orthologous to human CYP27A1 (Cytochrome P450 family 27 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp27a1 Products (1)

mRNA Protein Name
NM_178847.3 NP_849178.2 sterol 26-hydroxylase, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables Hsp70 protein binding IDA
IDA: Inferred from direct assay
19401463 RGD
enables cholesterol 26-hydroxylase activity IDA
IDA: Inferred from direct assay
2175615 RGD
enables vitamin D3 25-hydroxylase activity IDA
IDA: Inferred from direct assay
2175615 RGD
Biological Process GO Annotation Evidence Références Source
involved in cholesterol metabolic process IDA
IDA: Inferred from direct assay
2175615 RGD
Cellular Component GO Annotation Evidence Références Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
19401463 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sterol 26-hydroxylase, mitochondrial

  • 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase

  • 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase

  • cytochrome P-450c27/25

  • cytochrome P450 27

  • sterol 27-hydroxylase

  • vitamin D(3) 25-hydroxylase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-130705A Tachysterol 3 99.68% Unkown
HY-16670 Dafadine-A Inhibitor 98.94% Unkown
HY-138115 7ß,27-Dihydroxycholesterol Activator 99.58% Unkown
HY-173191 SK-124 Inhibitor 95.0% Unkown
HY-154825 20-Hydroxyvitamin D3 ≥98.0% Unkown
HY-139067 25(S)-27-Hydroxy cholesterol Activator / Unkown
HY-176497 GW273297X Inhibitor / Unkown
HY-RS03450 CYP27A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03451 CYP27B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03452 CYP27C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16287 Cyp27b1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS17011 Cyp27a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23454 Cyp27a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25766 Cyp27b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp27a1 NCBI NCBI:1593