CENPK - centromere protein K Gene

Also Known as P33; Solt; CENP-K; FKSG14; AF5alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64105

About CENPK

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:65,495,624-65,563,168 (from NCBI)

This gene has 17 transcripts (splice variants) and 197 orthologues. Broad expression in testis (RPKM 1.8), bone marrow (RPKM 1.7) and 19 other tissues.

Summary

CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

CENPK Products (5)

mRNA Protein Name
NM_001267038.2 NP_001253967.1 centromere protein K isoform 1
NM_001349367.2 NP_001336296.1 centromere protein K isoform 3
NM_001349368.2 NP_001336297.1 centromere protein K isoform 4
NM_001349369.2 NP_001336298.1 centromere protein K isoform 5
NM_022145.5 NP_071428.2 centromere protein K isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
24981860 GOA
Cellular Component GO Annotation Evidence Références Source
part of inner kinetochore IPI
IPI: Inferred from physical interaction
36085283 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPK Protein Structure

CENP-K

CENP-K: Centromere-associated protein K (2 - 269)

  • 0
  • 100
  • 200
  • 269 a.a.
Protein Preferred Names Protein Names

centromere protein K

  • SoxLZ/Sox6-binding protein Solt

CENPK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
CENPK Q9BS16 CENPH Homo sapiens Q9H3R5
Y2H Prey Pooling
25416956
Intra
CENPK Q9BS16 CENPH Homo sapiens Q9H3R5
Validated Y2H
32296183
Intra
CENPK Q9BS16 CENPI Homo sapiens Q92674
Anti Tag CoIP
33961781
Intra
CENPK Q9BS16 CENPI Homo sapiens Q92674
TAP
24981860
Intra
CENPK Q9BS16 PEX14 Homo sapiens O75381
Y2H Prey Pooling
32296183
Intra
CENPK Q9BS16 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
32296183
Intra
CENPK Q9BS16 MRFAP1L1 Homo sapiens Q96HT8
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-W000800 cis,cis-Muconic acid 98.54% Unkown
HY-RS02483 CENPK Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CENPK VGNC VGNC:60756
Canis familiaris CENPK VGNC VGNC:39106
Rattus norvegicus CENPK RGD RGD:1310461
Bos taurus CENPK VGNC VGNC:27179
Macaca mulatta CENPK VGNC VGNC:71136
Mus musculus CENPK MGD MGI:1926210
Others CENPK NCBI