KLF10 - KLF transcription factor 10 Gene

Also Known as EGRA; TIEG; TIEG1; EGR-alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7071

About KLF10

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:102,648,784-102,655,725 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues and 22 paralogues. Ubiquitous expression in bone marrow (RPKM 49.9), gall bladder (RPKM 37.2) and 25 other tissues.

Summary

This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

KLF10 Products (2)

mRNA Protein Name
NM_001032282.4 NP_001027453.1 Krueppel-like factor 10 isoform b
NM_005655.4 NP_005646.1 Krueppel-like factor 10 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15087465 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15087465 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10976766 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Références Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15087465 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLF10 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (385 - 411)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (416 - 438)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 480 a.a.
Protein Preferred Names Protein Names

Krueppel-like factor 10

  • Kruppel like factor 10

KLF10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
KLF10 Q13118 SP1 Homo sapiens P08047
Y2H
10976766
Cross: Cross-species interaction Intra: Intraspecies interaction

KLF10 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P82604 KLF10 Antibody (YA2349) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Brain Cancer

  • Adult Brain Tumor

  • Malignant Neoplasm Of Brain

  • Brain Neoplasms

  • Brain Neoplasm

  • Neoplasm Of Brain

  • Primary Malignant Neoplasm Of Brain

  • Brain Tumors

  • Adult Malignant Brain Neoplasm

  • Brain Neoplasm, Adult

  • Bt - Brain Tumour

  • Malignant Brain Tumour

  • Malignant Primary Brain Neoplasm

  • Malignant Primary Brain Tumor

  • Malignant Tumor Of Adult Brain

  • Malignant Tumor Of Brain

  • Primary Brain Neoplasm

  • Primary Brain Tumor

  • Tumor Of The Brain

  • Brain Tumor, Adult

  • Brain Tumor Primary

  • Malignant Primary Brain Tumors

  • Primary Brain Tumors

  • Cancer, Brain

  • Brain Tumor, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-W181026 KLF10-IN-1 99.84% Unkown
HY-RS07331 KLF10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19210 Klf10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25699 Klf10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KLF10 VGNC VGNC:42431
Bos taurus KLF10 VGNC VGNC:30627
Felis catus KLF10 VGNC VGNC:63130
Mus musculus KLF10 MGD MGI:1101353
Rattus norvegicus KLF10 RGD RGD:621652
Macaca mulatta KLF10 VGNC VGNC:73817
Others KLF10 NCBI