KLF10 - KLF transcription factor 10 Gene

Homo sapiens

Also known as EGRA; TIEG; TIEG1; EGR-alpha

Gene ID: 7071 | Gene type: protein coding

About KLF10

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:102,648,784-102,655,725 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues and 22 paralogues. Ubiquitous expression in bone marrow (RPKM 49.9), gall bladder (RPKM 37.2) and 25 other tissues.

Summary

This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

KLF10 Products(2)

mRNA	Protein	Name
NM_001032282.4	NP_001027453.1	Krueppel-like factor 10 isoform b
NM_005655.4	NP_005646.1	Krueppel-like factor 10 isoform a

KLF10 Protein Structure

zf-H2C2_2

0
100
200
300
400
480 a.a.

Protein Preferred Names

Protein Names

Krueppel-like factor 10

Kruppel like factor 10

Related Diseases

Diseases

Alias

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07331	KLF10 Human Pre-designed siRNA Set A		/	Unkown
HY-W181026	KLF10-IN-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KLF10	VGNC	VGNC:42431
Bos taurus	KLF10	VGNC	VGNC:30627
Felis catus	KLF10	VGNC	VGNC:63130
Mus musculus	KLF10	MGD	MGI:1101353
Rattus norvegicus	KLF10	RGD	RGD:621652
Macaca mulatta	KLF10	VGNC	VGNC:73817

Name
Email *

	Sorry, but the email address you supplied was invalid.