IGFN1 - immunoglobulin like and fibronectin type III domain containing 1 Gene

Also Known as EEF1A2BP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91156

About IGFN1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:201,190,824-201,228,952 (from NCBI)

This gene has 5 transcripts (splice variants), 141 orthologues and 9 paralogues. Biased expression in endometrium (RPKM 9.4), testis (RPKM 3.4) and 5 other tissues.

Summary

Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules; retina layer formation; and synapse assembly. Predicted to be located in Z disc and nucleus. Predicted to be active in synapse. [provided by Alliance of Genome Resources, Apr 2022]

IGFN1 Products (2)

mRNA Protein Name
NM_001164586.2 NP_001158058.1 immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform 1
NM_001367841.1 NP_001354770.1 immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGFN1 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (74 - 156)

I-set

I-set: Immunoglobulin I-set domain (166 - 257)

fn3

fn3: Fibronectin type III domain (268 - 346)

fn3

fn3: Fibronectin type III domain (363 - 445)

fn3

fn3: Fibronectin type III domain (465 - 548)

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  • 608 a.a.
Protein Preferred Names Protein Names

immunoglobulin-like and fibronectin type III domain-containing protein 1

  • EEF1A2-binding protein 1

IGFN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
IGFN1 Q86VF2 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS06636 IGFN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IGFN1 RGD RGD:1565384
Felis catus IGFN1 VGNC VGNC:62891
Bos taurus IGFN1 VGNC VGNC:59401
Macaca mulatta IGFN1 VGNC VGNC:99976
Mus musculus IGFN1 MGD MGI:3045352
Others IGFN1 NCBI