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Cat. No.: HY-153719

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NSC111552

NSC111552 is a potent SARS-CoV-2 NSP14 MTase inhibitor. NSC111552 inhibits the FL-NAH binding to the SARS-CoV-2 NSP14 MTase with an IC₅₀ of 5.1 μM.

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CAS No.: 40420-48-2
Formule: C₁₂H₁₀O₃
Masse moléculaire:202.21

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

NSC111552 Chemical Structure

CAS No.: 40420-48-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

NSC111552 is a potent SARS-CoV-2 NSP14 MTase inhibitor. NSC111552 inhibits the FL-NAH binding to the SARS-CoV-2 NSP14 MTase with an IC₅₀ of 5.1 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	5.24 μM Compound: 5	Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 72 hrs by MTS assay Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 72 hrs by MTS assay	[PMID: 24368029]
HS27	IC₅₀	9.87 μM Compound: 5	Cytotoxicity against human HS27 cells assessed as cell viability after 72 hrs by MTS assay Cytotoxicity against human HS27 cells assessed as cell viability after 72 hrs by MTS assay	[PMID: 24368029]
Jurkat	IC₅₀	5.6 μM Compound: 5	Cytotoxicity against human Jurkat cells assessed as cell viability after 72 hrs by MTS assay Cytotoxicity against human Jurkat cells assessed as cell viability after 72 hrs by MTS assay	[PMID: 24368029]
NALM-6	IC₅₀	5.09 μM Compound: 5	Cytotoxicity against human NALM6 cells assessed as cell viability after 72 hrs by MTS assay Cytotoxicity against human NALM6 cells assessed as cell viability after 72 hrs by MTS assay	[PMID: 24368029]
Ramos	IC₅₀	0.75 μM Compound: 5	Cytotoxicity against human Ramos cells assessed as cell viability after 72 hrs by MTS assay Cytotoxicity against human Ramos cells assessed as cell viability after 72 hrs by MTS assay	[PMID: 24368029]

Chemical Information

CAS No. 40420-48-2
Masse moléculaire 202.21
Formule C₁₂H₁₀O₃
SMILES

O=C(C)C1=C(O)C2=C(C=CC=C2)C(O)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Samrat SK, et al. A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases. Emerg Microbes Infect. 2023 Dec;12(1):2204164. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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