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Cat. No.: HY-P11893

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PSMA-HK9

PSMA-HK9 is a ligand targeting prostate-specific membrane antigen (PSMA) that binds to PSMA with high affinity, with a K_d value of 4.76 nM. PSMA-HK9 can be labeled with the diagnostic radionuclide 68Ga for imaging applications, and this labeled conjugate exhibits high tumor uptake and low normal tissue uptake in vivo. PSMA-HK9 can be labeled with the radionuclide 177Lu for targeted radionuclide studies, and this labeled conjugate possesses efficient cellular endocytosis and tumor inhibitory activity. PSMA-HK9 can be used in studies related to prostate cancer.

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Formule: C₅₉H₇₉N₁₁O₂₂
Masse moléculaire:1294.32

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Synthèse personnalisée de peptides

PSMA-HK9 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

PSMA

4.76 nM (Kd)

In Vitro

PSMA-HK9 binds to purified PSMA protein with high affinity, with a K_d value of 4.76 nM and a predicted binding energy of -9.7 kcal·mol⁻¹^[1].
PSMA-HK9 (120 min) competitively inhibits PSMA binding in RM1-PSMA cells, with a K_i value of 0.50 nM, exhibiting high target specificity and affinity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 1294.32
Formule C₅₉H₇₉N₁₁O₂₂
Sequence

{Tetraxetan}-{d-Glu}-{d-Glu}-{Amb}-{b-hAla(2-naphthyl)}-{d-Orn}-{CO}-{d-Glu}
Sequence Shortening

{Tetraxetan}-{d-Glu}-{d-Glu}-{Amb}-{b-hAla(2-naphthyl)}-{d-Orn}-{CO}-{d-Glu}
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Gao X, et al. Synthesis, Evaluation, and First-in-Human Study of a Novel PSMA Radioligand Bearing Beta-Amino Acid Linkage. Journal of medicinal chemistry. 2026 Mar 12;69(5):5610-5621.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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